{"id":"W2160275987","doi":"10.1177/1087057103252605","title":"Development of a Versatile Platform for Nuclear Receptor Screening Using AlphaScreen™","year":2003,"lang":"en","type":"article","venue":"SLAS DISCOVERY","topic":"Estrogen and related hormone effects","field":"Biochemistry, Genetics and Molecular Biology","cited_by":29,"is_retracted":false,"has_abstract":false,"ca_institutions":"PerkinElmer Biosignal","funders":"","keywords":"Coactivator; Receptor; Nuclear receptor; Biotinylation; Biology; Nuclear receptor coactivator 2; Computational biology; Biochemistry; Transcription factor","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0005135449,0.0006777715,0.0006360972,0.0004928135,0.0004724791,0.0006139023,0.0009144538,0.0004970272,0.003053832],"category_scores_gemma":[0.0003199333,0.0005567691,0.0006786475,0.000272042,0.0002576146,0.0003981597,0.0005749842,0.00106291,0.002848027],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003900957,"about_ca_system_score_gemma":0.0004214459,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0009406417,"about_ca_topic_score_gemma":0.001559975,"domain_scores_codex":[0.9997402,0.0000347061,0.00001575778,0.00005627566,0.00009160648,0.00006146428],"domain_scores_gemma":[0.9998525,0.00003919169,0.00001765536,0.00003207772,0.00002531871,0.00003324659],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001085271,0.00004362316,0.00009800964,0.00004459224,0.00001592302,0.00006826084,0.00002951848,0.0002791292,0.9883142,0.000516492,0.000474686,0.01000716],"study_design_scores_gemma":[0.00002717267,0.00013207,0.0002437849,0.000003720937,0.0000166464,0.000147246,0.00001033472,0.002103531,0.9884613,0.0001300265,0.008711928,0.00001219574],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"methods","genre_gemma":"empirical","genre_scores_codex":[0.4528469,0.001004629,0.5249836,0.0007287379,0.000261012,0.0009375267,0.002105152,0.006537986,0.01059435],"genre_scores_gemma":[0.6435996,0.001002681,0.3162622,0.0003032546,0.00004023558,0.0009647122,0.007677228,0.0005344736,0.02961569],"genre_candidate":"empirical","genre_consensus":null,"teacher_disagreement_score":0.003053832,"threshold_uncertainty_score":0.01021612,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02117314155664905,"score_gpt":0.2563977483528131,"score_spread":0.2352246067961641,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}