{"id":"W2160276745","doi":"10.1038/sj.onc.1204817","title":"Human homologue of Drosophila lats, LATS1, negatively regulate growth by inducing G2/M arrest or apoptosis","year":2001,"lang":"en","type":"article","venue":"Oncogene","topic":"Hippo pathway signaling and YAP/TAZ","field":"Biochemistry, Genetics and Molecular Biology","cited_by":119,"is_retracted":false,"has_abstract":false,"ca_institutions":"","funders":"Medical Research Council Canada; Yale Cancer Center","keywords":"Biology; Cyclin-dependent kinase 1; Cell cycle checkpoint; Cell cycle; Apoptosis; Cell biology; Cell growth; Suppressor; Tumor suppressor gene; Mutant; Cancer research; Gene; Molecular biology; Carcinogenesis; Genetics","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00006587784,0.0005361673,0.0001544447,0.0002730734,0.0002574263,0.0002307182,0.0001167263,0.0001856977,0.001351573],"category_scores_gemma":[0.00008401727,0.0001316669,0.0001744989,0.0001188547,0.0002153494,0.0001470758,0.0001991714,0.0003096965,0.0008977947],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004173386,"about_ca_system_score_gemma":0.0001473623,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003237363,"about_ca_topic_score_gemma":0.001075828,"domain_scores_codex":[0.9999536,0.000005884646,0.000003620809,0.00001037172,0.00001028259,0.0000163133],"domain_scores_gemma":[0.9999195,0.000008468318,0.00003173041,0.000006843153,0.000008319992,0.00002512094],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001989665,0.0000110669,0.0004378923,0.0000270505,0.000004856692,0.0001304664,0.0000077796,0.00005560575,0.9973887,0.0001632591,0.0002233815,0.00135102],"study_design_scores_gemma":[0.00004167012,0.0001777366,0.0151448,0.000009721491,0.00002482666,0.001257054,0.00005398457,0.001111926,0.9738544,0.0001777155,0.008141316,0.000004964897],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.991213,0.003258697,0.001518346,0.0002267315,0.00004853126,0.00001382347,0.0006300547,0.0001458369,0.002944914],"genre_scores_gemma":[0.990169,0.001245801,0.001205045,0.000119138,0.00002030105,0.00002328979,0.001815888,0.00003354767,0.005367929],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001351573,"threshold_uncertainty_score":0.00452143,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.020019340178055,"score_gpt":0.2655116086239454,"score_spread":0.2454922684458904,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}