{"id":"W2160309433","doi":"10.1016/j.bbapap.2006.03.004","title":"Isolation and characterization of cotiaractivase, a novel low molecular weight prothrombin activator from the venom of Bothrops cotiara","year":2006,"lang":"en","type":"article","venue":"Biochimica et Biophysica Acta (BBA) - Proteins and Proteomics","topic":"Venomous Animal Envenomation and Studies","field":"Biochemistry, Genetics and Molecular Biology","cited_by":25,"is_retracted":false,"has_abstract":false,"ca_institutions":"Queen's University","funders":"British Heart Foundation; GlaxoSmithKline","keywords":"Venom; Prothrombinase; Serine protease; Chemistry; PMSF; Biochemistry; Disintegrin; Bothrops jararaca; Snake venom; Metalloproteinase; Bothrops; Thrombin; Molecular mass; Viper Venoms; Activator (genetics); Enzyme; Molecular biology; Protease; Biology; Platelet","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001195374,0.0002340137,0.0002964702,0.00003440968,0.000145246,0.00004925723,0.000134112,0.0001522753,0.000003856562],"category_scores_gemma":[0.00002964558,0.0001866038,0.00008039111,0.0001104045,0.0003211612,0.00002479604,0.0001336561,0.000112089,4.992113e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001098566,"about_ca_system_score_gemma":0.00008598725,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000241581,"about_ca_topic_score_gemma":0.00001509121,"domain_scores_codex":[0.9988818,0.00007950592,0.0003624969,0.0003640817,0.0001497281,0.0001624373],"domain_scores_gemma":[0.9990807,0.00001978267,0.0004678072,0.0002834233,0.0001080574,0.00004027384],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002562683,0.000274462,0.0001258646,0.00007023815,0.00009981952,2.528671e-7,0.0001964413,0.00000215734,0.9981907,0.0006410416,0.00001361643,0.0001291271],"study_design_scores_gemma":[0.0007238847,0.0003876651,0.04535741,0.00006907328,0.00004284795,0.000002756305,0.00003870255,0.0002608421,0.9524955,0.0002118891,0.0002062771,0.0002031729],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9930494,0.0001238507,0.004220236,0.0007728558,0.00003162422,0.001375419,0.0003655082,0.00001108281,0.00004999433],"genre_scores_gemma":[0.9963023,0.0001569247,0.00281116,0.0001036151,0.0001253774,0.0001007446,0.0003453598,0.00003169338,0.00002283191],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.04569523,"threshold_uncertainty_score":0.7609484,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.005490759625277238,"score_gpt":0.2033226932679339,"score_spread":0.1978319336426567,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}