{"id":"W2160309433","doi":"10.1016/j.bbapap.2006.03.004","title":"Isolation and characterization of cotiaractivase, a novel low molecular weight prothrombin activator from the venom of Bothrops cotiara","year":2006,"lang":"en","type":"article","venue":"Biochimica et Biophysica Acta (BBA) - Proteins and Proteomics","topic":"Venomous Animal Envenomation and Studies","field":"Biochemistry, Genetics and Molecular Biology","cited_by":25,"is_retracted":false,"has_abstract":false,"ca_institutions":"Queen's University","funders":"British Heart Foundation; GlaxoSmithKline","keywords":"Venom; Prothrombinase; Serine protease; Chemistry; PMSF; Biochemistry; Disintegrin; Bothrops jararaca; Snake venom; Metalloproteinase; Bothrops; Thrombin; Molecular mass; Viper Venoms; Activator (genetics); Enzyme; Molecular biology; Protease; Biology; Platelet","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001223772,0.0006016728,0.0004652987,0.0003455773,0.0002557617,0.0004846781,0.00018423,0.0003998459,0.000515618],"category_scores_gemma":[0.0002226646,0.0001535404,0.0003701549,0.000295341,0.0002732357,0.0003295901,0.0001926648,0.0006148946,0.0003398076],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003102846,"about_ca_system_score_gemma":0.000396369,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.003419139,"about_ca_topic_score_gemma":0.003934594,"domain_scores_codex":[0.9999144,0.000006282892,0.000007189125,0.00002457927,0.00002234769,0.00002528471],"domain_scores_gemma":[0.9998112,0.00002700341,0.00003320079,0.0000220722,0.00004527756,0.00006118218],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00003625307,0.000008183094,0.000329582,0.00001538917,0.000003472661,0.0001114146,0.00002028676,0.00001339044,0.9986693,0.00002868959,0.00001815329,0.0007459416],"study_design_scores_gemma":[0.00006870857,0.0009240623,0.1588233,0.00002909798,0.0001414593,0.005331509,0.000195787,0.002206177,0.8191562,0.0001580203,0.01293875,0.0000266985],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9902329,0.00390786,0.003669717,0.0002712558,0.00005599582,0.00008319857,0.0007652097,0.00004391802,0.0009698138],"genre_scores_gemma":[0.9831144,0.002055536,0.005544915,0.0002201001,0.0000519393,0.00004248597,0.004360694,0.00003608235,0.004573918],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003419139,"threshold_uncertainty_score":0.006798446,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.005490759625277238,"score_gpt":0.2033226932679339,"score_spread":0.1978319336426567,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}