{"id":"W2160355632","doi":"10.1093/nar/gkp617","title":"Transient dsDNA breaks during pre-replication complex assembly","year":2009,"lang":"en","type":"article","venue":"Nucleic Acids Research","topic":"Cancer therapeutics and mechanisms","field":"Biochemistry, Genetics and Molecular Biology","cited_by":13,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University","funders":"Canadian Institutes of Health Research; University of Patras; Faculty of Medicine, McGill University; McGill University; Vanderbilt University Medical Center; Vanderbilt University","keywords":"Biology; DNA replication; Origin recognition complex; Replication protein A; Eukaryotic DNA replication; Topoisomerase; DNA; Replication factor C; Control of chromosome duplication; Cell biology; Pre-replication complex; DNA repair; Molecular biology; DNA replication factor CDT1; Licensing factor; Gene; DNA-binding protein; Genetics; Transcription factor","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001916936,0.0002209885,0.0002897893,0.0001529389,0.000167849,0.000552037,0.0002356316,0.0003096564,0.001768343],"category_scores_gemma":[0.0003331307,0.000231335,0.0001848566,0.0001042521,0.0001322937,0.0003506932,0.0002091406,0.0007039325,0.0007953061],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004838004,"about_ca_system_score_gemma":0.0001803407,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000364588,"about_ca_topic_score_gemma":0.0006060722,"domain_scores_codex":[0.999744,0.00002538273,0.00001559741,0.00007338302,0.00008568764,0.00005591803],"domain_scores_gemma":[0.9998019,0.0000341153,0.00005356158,0.00003158883,0.0000296607,0.00004916362],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00009963695,0.00001055498,0.0001773673,0.00002543527,0.000003621459,0.0000449904,0.00001535075,0.00005630879,0.9984072,0.0001348435,0.00003175224,0.0009930508],"study_design_scores_gemma":[0.000007839649,0.000134559,0.003680586,0.000004559097,0.000004924883,0.0001528314,0.00001388623,0.0003190208,0.9933481,0.00007043353,0.002259656,0.000003663917],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9847461,0.00479487,0.007550036,0.00008941416,0.00005073003,0.00004603007,0.0003092743,0.0002451569,0.002168375],"genre_scores_gemma":[0.9941513,0.0007794825,0.001834304,0.00004176861,0.00001013455,0.00003397416,0.0005620153,0.00002676117,0.002560169],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001768343,"threshold_uncertainty_score":0.005915701,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0521330011967575,"score_gpt":0.3687296026208036,"score_spread":0.3165966014240461,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}