{"id":"W2160355632","doi":"10.1093/nar/gkp617","title":"Transient dsDNA breaks during pre-replication complex assembly","year":2009,"lang":"en","type":"article","venue":"Nucleic Acids Research","topic":"Cancer therapeutics and mechanisms","field":"Biochemistry, Genetics and Molecular Biology","cited_by":13,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University","funders":"Canadian Institutes of Health Research; University of Patras; Faculty of Medicine, McGill University; McGill University; Vanderbilt University Medical Center; Vanderbilt University","keywords":"Biology; DNA replication; Origin recognition complex; Replication protein A; Eukaryotic DNA replication; Topoisomerase; DNA; Replication factor C; Control of chromosome duplication; Cell biology; Pre-replication complex; DNA repair; Molecular biology; DNA replication factor CDT1; Licensing factor; Gene; DNA-binding protein; Genetics; Transcription factor","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004928731,0.0001197668,0.0001128178,0.0000813603,0.000223385,0.00005800696,0.0003360127,0.0001417706,0.00007155467],"category_scores_gemma":[0.00002524177,0.0001195503,0.00007802013,0.0001820937,0.00006466125,0.000004734026,0.00006832395,0.0001997514,0.00002934883],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00005272116,"about_ca_system_score_gemma":0.00007288678,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00002645702,"about_ca_topic_score_gemma":0.00001717088,"domain_scores_codex":[0.9984008,0.00008658929,0.0001697793,0.0004949034,0.0003947821,0.0004531171],"domain_scores_gemma":[0.9988959,0.000007282765,0.00002982809,0.0007486513,0.0001850623,0.0001332496],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001660109,0.00009202778,0.00003873783,0.00001006549,0.00001923194,0.000002063744,0.0001018195,0.00001169528,0.96552,0.0006599266,0.0009197398,0.03245868],"study_design_scores_gemma":[0.0008467186,0.0008095846,0.04689693,0.00001476137,0.00000779067,0.00002316908,0.00006965813,0.0003817909,0.8072585,0.000531998,0.1429519,0.0002071152],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9896888,0.0002445755,0.001519099,0.00136444,0.0000490028,0.0003456506,0.0000142602,0.0000264655,0.006747747],"genre_scores_gemma":[0.9969503,0.0002683418,0.0004113231,0.0002995851,0.0002500895,0.00003045881,0.00006996631,0.00002396445,0.00169603],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1582614,"threshold_uncertainty_score":0.4875121,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0521330011967575,"score_gpt":0.3687296026208036,"score_spread":0.3165966014240461,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}