{"id":"W2160365238","doi":"10.1007/s12575-010-9029-5","title":"Quick and Simple Detection Technique to Assess the Binding of Antimicrotubule Agents to the Colchicine-Binding Site","year":2010,"lang":"en","type":"article","venue":"Biological Procedures Online","topic":"Cancer therapeutics and mechanisms","field":"Biochemistry, Genetics and Molecular Biology","cited_by":73,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université Laval; Hôpital Saint-François d'Assise","funders":"","keywords":"Tubulin; Colchicine; Iodoacetamide; Binding site; Chemistry; Adduct; Microtubule; Biochemistry; Biology; Cysteine; Cell biology; Genetics; Organic chemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003128833,0.0001275577,0.0001248575,0.00003382839,0.0001579766,0.00002243666,0.0002286196,0.00015427,0.00001015191],"category_scores_gemma":[0.0001917378,0.00006777242,0.00004617542,0.0001431335,0.0000594019,0.000002344225,0.0002099842,0.0001557401,0.000003043811],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000006827462,"about_ca_system_score_gemma":0.00003209824,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00002431422,"about_ca_topic_score_gemma":0.0006601019,"domain_scores_codex":[0.9992473,0.00003681153,0.0001694469,0.0002759825,0.00007500335,0.0001955289],"domain_scores_gemma":[0.9995379,0.00002462654,0.00007132773,0.000227131,0.00006857471,0.00007039068],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00009461819,0.00004176881,0.0006386027,0.00001100838,0.00001497536,3.15689e-7,0.00002590832,0.000009254068,0.9964098,0.00004217759,0.0002148888,0.002496727],"study_design_scores_gemma":[0.0001551635,0.0006408925,0.00364057,0.00001290508,0.00001180054,0.00002165211,0.00006479969,0.00003250321,0.9438805,0.00008150766,0.05133564,0.0001220498],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9936606,0.00006995465,0.004447608,0.0008177632,0.0001174233,0.0007175934,0.0001341909,0.00001295972,0.00002195553],"genre_scores_gemma":[0.9968571,0.0001159454,0.00117463,0.001410363,0.0002217883,0.00007775786,0.00007191136,0.00001209274,0.00005838464],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.05252924,"threshold_uncertainty_score":0.2763679,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0366281687727699,"score_gpt":0.3206340222591287,"score_spread":0.2840058534863588,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}