{"id":"W2160369707","doi":"10.1093/hmg/ddt080","title":"Investigating the contribution of VAPB/ALS8 loss of function in amyotrophic lateral sclerosis","year":2013,"lang":"en","type":"article","venue":"Human Molecular Genetics","topic":"Amyotrophic Lateral Sclerosis Research","field":"Medicine","cited_by":93,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université de Montréal; Hôpital de l'Enfant-Jésus; Centre Hospitalier de l’Université de Montréal","funders":"","keywords":"Biology; Amyotrophic lateral sclerosis; Loss function; Zebrafish; Gene knockdown; Mutant; Mutation; Genetics; Cell biology; Phenotype; Gene; Internal medicine; Disease; Medicine","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002144873,0.0004408674,0.0003705674,0.0004912243,0.0003104527,0.0002560428,0.0002999616,0.0007630192,0.001283524],"category_scores_gemma":[0.0002881311,0.0002491199,0.0003320188,0.0001908874,0.0003342958,0.0003160606,0.0003658592,0.0004816031,0.000474325],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000396011,"about_ca_system_score_gemma":0.0002364844,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001383884,"about_ca_topic_score_gemma":0.001250627,"domain_scores_codex":[0.9998456,0.00001470707,0.00001568124,0.00003549243,0.00005804381,0.00003033956],"domain_scores_gemma":[0.9998662,0.00001893299,0.00004141953,0.000007168411,0.00001879402,0.00004739013],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001971989,0.00005018207,0.002196576,0.00006261523,0.00001443377,0.0006072109,0.00002530528,0.0001140646,0.9951557,0.00004804609,0.00004184289,0.001486826],"study_design_scores_gemma":[0.0001503301,0.003437196,0.11466,0.00007723045,0.000233969,0.009950454,0.0003375228,0.005316812,0.8584237,0.0003333314,0.007038353,0.00004115055],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.996883,0.001319625,0.0009698396,0.00006660892,0.00001412576,0.00003200576,0.0003192871,0.00002740228,0.0003680826],"genre_scores_gemma":[0.9958439,0.001096561,0.00103721,0.00007173122,0.0000111716,0.00005705581,0.0005468847,0.00002624423,0.001309161],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001383884,"threshold_uncertainty_score":0.004293799,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03355073174271342,"score_gpt":0.2787975084964374,"score_spread":0.245246776753724,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}