{"id":"W2160369707","doi":"10.1093/hmg/ddt080","title":"Investigating the contribution of VAPB/ALS8 loss of function in amyotrophic lateral sclerosis","year":2013,"lang":"en","type":"article","venue":"Human Molecular Genetics","topic":"Amyotrophic Lateral Sclerosis Research","field":"Medicine","cited_by":93,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université de Montréal; Hôpital de l'Enfant-Jésus; Centre Hospitalier de l’Université de Montréal","funders":"","keywords":"Biology; Amyotrophic lateral sclerosis; Loss function; Zebrafish; Gene knockdown; Mutant; Mutation; Genetics; Cell biology; Phenotype; Gene; Internal medicine; Disease; Medicine","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002800055,0.0001384817,0.0002947011,0.0001224997,0.0000599923,0.00001906083,0.0001564968,0.0001090626,0.0001592267],"category_scores_gemma":[0.0001093406,0.0001031192,0.0000990634,0.000328638,0.0003347374,0.00004400842,0.0001061366,0.0002619614,0.00001717397],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00006658024,"about_ca_system_score_gemma":0.00005628277,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003740907,"about_ca_topic_score_gemma":0.00002048958,"domain_scores_codex":[0.9982957,0.0001737305,0.0005135186,0.0002123182,0.0005023164,0.0003023806],"domain_scores_gemma":[0.9989147,0.00003203943,0.000173436,0.0004109348,0.0003722275,0.00009666338],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.00001621136,0.00006672487,0.1034288,0.00003854217,0.00003989171,0.000003021244,0.0001199451,0.0002892229,0.8947756,0.0005699078,0.00008286489,0.0005691996],"study_design_scores_gemma":[0.001150195,0.0004184677,0.9381645,0.0002118146,0.00004261792,0.000003850349,0.00001925925,0.001443765,0.0561802,0.00224492,0.00003226048,0.00008817553],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9975284,0.0004500879,0.000340431,0.0008586561,0.00003403804,0.0006745916,0.000002422589,0.00001325136,0.00009806029],"genre_scores_gemma":[0.998987,0.00008236019,0.0003587058,0.0004169453,0.00003391789,0.00004275724,0.00002620534,0.00002538063,0.00002677193],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.8385954,"threshold_uncertainty_score":0.420508,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03355073174271342,"score_gpt":0.2787975084964374,"score_spread":0.245246776753724,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}