{"id":"W2160393148","doi":"10.1161/01.hyp.0000078357.92682.ec","title":"Endothelin Antagonism on Aldosterone-Induced Oxidative Stress and Vascular Remodeling","year":2003,"lang":"en","type":"article","venue":"Hypertension","topic":"Hormonal Regulation and Hypertension","field":"Medicine","cited_by":251,"is_retracted":false,"has_abstract":true,"ca_institutions":"Canadian Institutes of Health Research","funders":"Canadian Institutes of Health Research; Heart and Stroke Foundation of Canada","keywords":"Internal medicine; Endocrinology; Aldosterone; Mineralocorticoid receptor; Spironolactone; Mineralocorticoid; Endothelin 1; Chemistry; Hydralazine; Medicine; Receptor; Blood pressure","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001518241,0.0003224777,0.0004412842,0.000144677,0.0001545812,0.0002397728,0.0001699515,0.0002219947,0.0009832011],"category_scores_gemma":[0.0001781947,0.0001448679,0.0002426158,0.00009639317,0.0002505291,0.0001938565,0.0001768825,0.0007049493,0.0001748388],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001481324,"about_ca_system_score_gemma":0.0002237014,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004128296,"about_ca_topic_score_gemma":0.00106922,"domain_scores_codex":[0.999828,0.00003778098,0.00001581521,0.00001928458,0.0000473176,0.00005179707],"domain_scores_gemma":[0.9998277,0.00002034899,0.00004218483,0.00001109798,0.00001590407,0.00008269998],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.002270567,0.0002036905,0.0004803464,0.00005176273,0.00002286903,0.00007203258,0.00001837091,0.00006524442,0.992573,0.00004440127,0.00004248683,0.0041553],"study_design_scores_gemma":[0.0007582075,0.01237769,0.04797997,0.00002057928,0.0001904563,0.0005802777,0.0001055398,0.001261369,0.9343593,0.0001466423,0.00219641,0.00002359521],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9976386,0.001260662,0.0003478552,0.00004614844,0.0000243492,0.00001101348,0.00007396228,0.00002894872,0.0005684429],"genre_scores_gemma":[0.9966087,0.001238286,0.0006780448,0.00007303941,0.00003320557,0.00002830621,0.0002321409,0.000009763639,0.00109854],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0009832011,"threshold_uncertainty_score":0.003289163,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04772814902948865,"score_gpt":0.2688170177003367,"score_spread":0.2210888686708481,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}