{"id":"W2160410866","doi":"10.1016/j.cell.2013.09.042","title":"Hypermutation of the Inactive X Chromosome Is a Frequent Event in Cancer","year":2013,"lang":"en","type":"article","venue":"Cell","topic":"Genetics and Neurodevelopmental Disorders","field":"Biochemistry, Genetics and Molecular Biology","cited_by":85,"is_retracted":false,"has_abstract":true,"ca_institutions":"SickKids Foundation; Hospital for Sick Children","funders":"Canadian Institutes of Health Research","keywords":"Biology; Somatic hypermutation; Genetics; Carcinogenesis; Genome; Autosome; Mutation rate; Chromosome; Cancer; Mutation; Cancer research; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00001554571,0.00005029826,0.00004296751,0.00001120332,0.00001342472,0.000003096869,0.00007988865,0.00003319415,0.00008368411],"category_scores_gemma":[0.000003645489,0.00003842113,0.00002847482,0.00004897814,0.00002349304,0.000001134141,0.00004648796,0.00002867262,0.00001030748],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001283135,"about_ca_system_score_gemma":0.0000416578,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002158192,"about_ca_topic_score_gemma":0.00006875413,"domain_scores_codex":[0.9996606,0.00001461856,0.00008586753,0.0001095016,0.00005274848,0.0000766895],"domain_scores_gemma":[0.9998167,0.000001575741,0.0000390492,0.0001023427,0.00002552204,0.00001476854],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000002445333,0.00004844398,0.004550633,0.000009583689,0.000003639208,8.029084e-8,0.0001449961,0.00008364965,0.9940366,0.000001570932,0.0005701066,0.0005482592],"study_design_scores_gemma":[0.0001865555,0.00003160658,0.1978351,0.000005856761,0.000001963788,2.606806e-7,0.00008006651,0.0000301645,0.8003739,0.00008755705,0.00132275,0.00004422836],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9981917,0.0002736263,0.000009236598,0.0001776111,0.00006974865,0.0001700089,0.000005891646,7.26781e-7,0.001101427],"genre_scores_gemma":[0.9989421,0.0002133136,0.00003270197,0.0003278094,0.000005102258,0.00004252179,0.000005744789,0.000005947928,0.0004247374],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1936627,"threshold_uncertainty_score":0.1566768,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.00714790296414339,"score_gpt":0.2265625274975503,"score_spread":0.2194146245334069,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}