{"id":"W2160410866","doi":"10.1016/j.cell.2013.09.042","title":"Hypermutation of the Inactive X Chromosome Is a Frequent Event in Cancer","year":2013,"lang":"en","type":"article","venue":"Cell","topic":"Genetics and Neurodevelopmental Disorders","field":"Biochemistry, Genetics and Molecular Biology","cited_by":85,"is_retracted":false,"has_abstract":true,"ca_institutions":"SickKids Foundation; Hospital for Sick Children","funders":"Canadian Institutes of Health Research","keywords":"Biology; Somatic hypermutation; Genetics; Carcinogenesis; Genome; Autosome; Mutation rate; Chromosome; Cancer; Mutation; Cancer research; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003054068,0.0002278881,0.0003153151,0.001141432,0.0002743537,0.0003041452,0.0001824141,0.0002826788,0.0009155187],"category_scores_gemma":[0.0005613939,0.0001163103,0.0001594094,0.0006600271,0.0002888432,0.0001779939,0.0003834045,0.0002018408,0.0001555125],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001413902,"about_ca_system_score_gemma":0.0001183457,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005487234,"about_ca_topic_score_gemma":0.0007469214,"domain_scores_codex":[0.999684,0.00005040041,0.00002963563,0.00008540016,0.0001129147,0.00003770833],"domain_scores_gemma":[0.9996015,0.0000985228,0.0001619735,0.00004658963,0.00003726627,0.00005417392],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.0004391324,0.00002839916,0.1725933,0.0001292716,0.0001611007,0.0007218242,0.0001753466,0.0002318333,0.814018,0.0002558497,0.00007042923,0.01117552],"study_design_scores_gemma":[0.000007488261,0.0002867547,0.870149,0.00001019671,0.00008631862,0.005810893,0.0001605077,0.0003623978,0.1205133,0.000237066,0.00236667,0.000009357899],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9979056,0.0009778662,0.000591278,0.000014956,0.000002806676,0.000004860878,0.0001801089,0.00001348796,0.0003090693],"genre_scores_gemma":[0.9984731,0.0003984917,0.0004921475,0.00001896916,0.000004246062,0.000003686489,0.0003741573,0.000006101433,0.000228955],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001141432,"threshold_uncertainty_score":0.003062725,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.00714790296414339,"score_gpt":0.2265625274975503,"score_spread":0.2194146245334069,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}