{"id":"W2160421516","doi":"10.1242/jcs.062612","title":"The p75NTR intracellular domain generated by neurotrophin-induced receptor cleavage potentiates Trk signaling","year":2010,"lang":"en","type":"article","venue":"Journal of Cell Science","topic":"Nerve injury and regeneration","field":"Neuroscience","cited_by":76,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University; Montreal Neurological Institute and Hospital","funders":"York University; McGill University; Canadian Institutes of Health Research; Hospital for Sick Children; University of Miami","keywords":"Trk receptor; Neurotrophin; Low-affinity nerve growth factor receptor; Intracellular; Tropomyosin receptor kinase A; Cell biology; Biology; Nerve growth factor; Signal transduction; Cleavage (geology); Protein kinase B; Receptor; Biochemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["sts"],"consensus_categories":[],"category_scores_codex":[0.002131323,0.000158534,0.0001614428,0.0001239799,0.001426889,0.0005914776,0.00114725,0.00007383719,0.00004931662],"category_scores_gemma":[0.0005691018,0.00009568098,0.0001049473,0.0008097027,0.0006005338,0.0007550335,0.0000749677,0.0007399442,0.00003323528],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00003417322,"about_ca_system_score_gemma":0.0002394073,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000003114751,"about_ca_topic_score_gemma":0.000001878034,"domain_scores_codex":[0.9975284,0.0002376467,0.0005519128,0.0003172298,0.0009261025,0.0004387484],"domain_scores_gemma":[0.9984406,0.0002157092,0.0006147432,0.0002756739,0.000210277,0.0002429543],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00003831599,0.00006464331,0.00001067465,0.000002134727,0.000001149309,0.00002418631,0.00008835938,0.00009200201,0.9968494,0.0004216024,0.001265559,0.001142018],"study_design_scores_gemma":[0.0002618788,0.0002280045,0.00002298869,0.000007061671,0.000007136562,0.00008773786,0.00004133856,0.00080571,0.9928789,0.0003769655,0.005154408,0.000127897],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9940272,0.00009576263,0.0006473284,0.001585025,0.003169133,0.0001279326,0.000002748632,0.00001701971,0.0003278644],"genre_scores_gemma":[0.997518,0.00007688619,0.001151769,0.0003021327,0.0004960987,0.000001607275,3.117883e-7,0.00001414978,0.0004390255],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003970482,"threshold_uncertainty_score":0.9998731,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01177258565529236,"score_gpt":0.2370178019348126,"score_spread":0.2252452162795202,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}