{"id":"W2160438188","doi":"10.2967/jnumed.109.074344","title":"A New Pyrimidine-Specific Reporter Gene: A Mutated Human Deoxycytidine Kinase Suitable for PET During Treatment with Acycloguanosine-Based Cytotoxic Drugs","year":2010,"lang":"en","type":"article","venue":"Journal of Nuclear Medicine","topic":"Virus-based gene therapy research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":62,"is_retracted":false,"has_abstract":true,"ca_institutions":"University Health Network; Ontario Institute for Cancer Research; University of Toronto","funders":"National Cancer Institute; National Institutes of Health; Memorial Sloan-Kettering Cancer Center","keywords":"Deoxycytidine kinase; Ganciclovir; Thymidine kinase; Penciclovir; Chemistry; Reporter gene; In vivo; Prodrug; Nucleoside analogue; Deoxycytidine; Gemcitabine; Molecular biology; Biology; Nucleoside; Biochemistry; Herpes simplex virus; Virology; Human cytomegalovirus; Gene; Virus; Gene expression; Cancer","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002629125,0.0005731581,0.0003749434,0.0001937908,0.0001013702,0.0005106742,0.0004669082,0.0008118841,0.0007210638],"category_scores_gemma":[0.0002387592,0.0002084571,0.0003040255,0.0002259931,0.0003430576,0.0004356063,0.0002175627,0.0006268938,0.0003942562],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005929815,"about_ca_system_score_gemma":0.0003220602,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000445993,"about_ca_topic_score_gemma":0.0003828806,"domain_scores_codex":[0.9997578,0.0000397016,0.00001971849,0.00008014691,0.00006414138,0.00003858418],"domain_scores_gemma":[0.9998313,0.00003116306,0.00005903714,0.00001860024,0.00002972841,0.00003023685],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00008733999,0.00001222503,0.0001651383,0.00005856849,0.00000419042,0.00005539392,0.00001410584,0.0001725495,0.9976587,0.0001531219,0.00004204056,0.001576593],"study_design_scores_gemma":[0.000009965404,0.0001101559,0.0004333114,0.000003564237,0.00001223852,0.0004642067,0.000006202579,0.0007218599,0.9955637,0.0000155734,0.002653873,0.000005287799],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.8910564,0.007393194,0.09560808,0.0004370579,0.0001968479,0.0002922605,0.001207797,0.000612221,0.003196075],"genre_scores_gemma":[0.9293772,0.002806148,0.06237286,0.0001271585,0.00003623824,0.0001775488,0.001366285,0.0001158688,0.003620645],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0008118841,"threshold_uncertainty_score":0.004302382,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01881574542710453,"score_gpt":0.2957002674687772,"score_spread":0.2768845220416727,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}