{"id":"W2160454557","doi":"10.1128/aac.01159-06","title":"Antiparasitic Drug Nitazoxanide Inhibits the Pyruvate Oxidoreductases of <i>Helicobacter pylori</i> , Selected Anaerobic Bacteria and Parasites, and <i>Campylobacter jejuni</i>","year":2006,"lang":"en","type":"article","venue":"Antimicrobial Agents and Chemotherapy","topic":"Helicobacter pylori-related gastroenterology studies","field":"Medicine","cited_by":242,"is_retracted":false,"has_abstract":true,"ca_institutions":"Dalhousie University","funders":"Health Canada","keywords":"Thiamine pyrophosphate; Anaerobic bacteria; Campylobacter jejuni; Cofactor; Nitazoxanide; Entamoeba histolytica; Biochemistry; Biology; Microbiology; Pyruvate decarboxylation; Chemistry; Pyruvate dehydrogenase complex; Bacteria; Enzyme","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0001807518,0.0004870323,0.0007300957,0.0001392898,0.0002571084,0.00008468432,0.0001179751,0.0001670736,0.00004045224],"category_scores_gemma":[0.00001943116,0.0003503911,0.00008129375,0.0003626609,0.000757554,0.0001903375,0.0001013051,0.0003061021,0.000005117329],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002660035,"about_ca_system_score_gemma":0.00003671162,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003944082,"about_ca_topic_score_gemma":0.0001162949,"domain_scores_codex":[0.9979479,0.0001055271,0.0005984915,0.0005899313,0.0001693206,0.0005888582],"domain_scores_gemma":[0.9989977,0.00006497345,0.000246277,0.0003270438,0.0002206573,0.0001432826],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.000470721,0.0003601284,0.556985,0.0001475582,0.0005179919,0.00002362337,0.0005793755,5.735955e-7,0.4205726,0.00002520501,0.01908137,0.001235795],"study_design_scores_gemma":[0.004044154,0.0002958439,0.8943747,0.0002280475,0.0003023278,0.0003116744,0.00007484607,0.00001174052,0.09345208,0.00003440521,0.006567661,0.0003025701],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9896666,0.0003566512,0.000007154513,0.009009188,0.0001500965,0.0005713799,0.00009226381,0.00006928375,0.00007733532],"genre_scores_gemma":[0.9865465,0.003213284,0.0004368076,0.009124709,0.00019773,0.00001154798,0.0001234634,0.00006441356,0.00028153],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.3373896,"threshold_uncertainty_score":0.9998948,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.007081957431604919,"score_gpt":0.2256319066722463,"score_spread":0.2185499492406414,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}