{"id":"W2160456150","doi":"10.1186/2194-7511-2-5","title":"Circadian biomarkers in patients with bipolar disorder: promising putative predictors of lithium response","year":2014,"lang":"en","type":"article","venue":"International Journal of Bipolar Disorders","topic":"Bipolar Disorder and Treatment","field":"Medicine","cited_by":32,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"National Institute of Mental Health; Canadian Network for Mood and Anxiety Treatments; International Society for Bipolar Disorders","keywords":"Circadian rhythm; Bipolar disorder; Lithium (medication); Internal medicine; Medicine; Neurology; Treatment of bipolar disorder; Psychopharmacology; Psychology; Psychiatry; Dark therapy; Oncology; Mania","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000710985,0.0002486337,0.0004518996,0.0009835551,0.00004470992,0.00002742017,0.0002930447,0.000112822,0.00003801178],"category_scores_gemma":[0.0004426833,0.0001934503,0.0002123274,0.0003711479,0.0002082287,0.0003093067,0.0000435574,0.0003256419,0.000004263915],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002122586,"about_ca_system_score_gemma":0.0002571404,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002104253,"about_ca_topic_score_gemma":0.0002612309,"domain_scores_codex":[0.9975167,0.000262129,0.0007514257,0.0002364024,0.0009661242,0.0002672125],"domain_scores_gemma":[0.9982163,0.000221547,0.0006019187,0.0001982302,0.0005744383,0.0001875249],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.006679046,0.001341701,0.9291153,0.00003025592,0.001338242,0.000006943591,0.00133333,0.00006522206,0.000245491,0.00004573963,0.00002321288,0.05977552],"study_design_scores_gemma":[0.009853004,0.00235711,0.9543895,0.0003110966,0.0001706935,0.00002582599,0.0002870747,0.00009602953,0.0003643451,0.0001511793,0.03182146,0.0001726743],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.989714,0.006769391,0.001132706,0.001338912,0.0003979511,0.0004065523,0.0000492684,0.0000145997,0.0001766626],"genre_scores_gemma":[0.9984601,0.0004572246,0.0008415201,0.0000643201,0.00006014976,0.000005597033,0.0000445605,0.00004175025,0.00002482644],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.05960285,"threshold_uncertainty_score":0.7888674,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.004265798371750049,"score_gpt":0.2345806919354064,"score_spread":0.2303148935636563,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}