{"id":"W2160457008","doi":"10.1111/j.1365-2141.2009.07881.x","title":"Phase II study of the histone deacetylase inhibitor MGCD0103 in patients with previously treated chronic lymphocytic leukaemia","year":2009,"lang":"en","type":"article","venue":"British Journal of Haematology","topic":"Chronic Lymphocytic Leukemia Research","field":"Medicine","cited_by":114,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université de Montréal; Pyrogenesis (Canada); Princess Margaret Cancer Centre; Ottawa Hospital; Queen Elizabeth II Health Sciences Centre","funders":"National Cancer Institute; D. Warren Brown Family Foundation; Leukemia and Lymphoma Society","keywords":"Fludarabine; Medicine; Chronic lymphocytic leukemia; Rituximab; Internal medicine; Concomitant; Histone deacetylase inhibitor; Histone deacetylase; Tolerability; Gastroenterology; Pharmacokinetics; Toxicity; Refractory (planetary science); Oncology; Pharmacology; Lymphoma; Leukemia; Chemotherapy; Adverse effect; Histone; Biology; Cyclophosphamide","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004686207,0.000223884,0.001182864,0.0002911874,0.0001162762,0.00001632761,0.0003657461,0.0001603413,0.0000671148],"category_scores_gemma":[0.0004063634,0.0001685199,0.0001548441,0.0005860933,0.0002671132,0.0001481609,0.00009374249,0.0005675195,0.00000355875],"about_ca_system_candidate":true,"about_ca_system_consensus":true,"about_ca_system_score_codex":0.01790298,"about_ca_system_score_gemma":0.01002277,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0008165148,"about_ca_topic_score_gemma":0.000755989,"domain_scores_codex":[0.9968563,0.0003103668,0.001184719,0.0002837692,0.0008275681,0.0005372245],"domain_scores_gemma":[0.9980873,0.0001031331,0.0006600156,0.0004258223,0.0005048175,0.0002189283],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"case_report","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.06390862,0.1422496,0.09328916,0.002887887,0.003266839,0.3863253,0.01274758,0.001726574,0.005330049,0.0001488163,0.02542494,0.2626946],"study_design_scores_gemma":[0.6420203,0.09107033,0.04395428,0.005422462,0.0008946304,0.2054306,0.0005905585,0.0009535858,0.008825337,0.00006379627,0.0002620048,0.0005121101],"study_design_candidate":"randomized_trial","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9956343,0.002771391,0.000004780979,0.000117021,0.0001240408,0.001226386,0.00000471618,0.00001270467,0.0001046782],"genre_scores_gemma":[0.9994753,0.0001073302,0.00005375635,0.0001007278,0.00007492834,0.00001014435,0.00000469968,0.00003009153,0.0001429977],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.5781116,"threshold_uncertainty_score":0.9955895,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.009130678814489193,"score_gpt":0.2905438412582437,"score_spread":0.2814131624437545,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}