{"id":"W2160463964","doi":"10.1158/1078-0432.ccr-14-2666","title":"Androgen Receptor Gene Aberrations in Circulating Cell-Free DNA: Biomarkers of Therapeutic Resistance in Castration-Resistant Prostate Cancer","year":2015,"lang":"en","type":"article","venue":"Clinical Cancer Research","topic":"Prostate Cancer Treatment and Research","field":"Medicine","cited_by":479,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia; BC Cancer Agency","funders":"","keywords":"Prostate cancer; Androgen receptor; Medicine; Cancer research; Prostate; Androgen; Cancer; Castration; Oncology; Internal medicine; Hormone","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.004228184,0.0001974184,0.000585645,0.0004622063,0.0001034013,0.00003948536,0.0003325237,0.0002100153,0.0001916445],"category_scores_gemma":[0.0007756774,0.0001639863,0.0001214219,0.001795161,0.0006281409,0.0001536604,0.0001435307,0.0008565205,0.00001311807],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001139066,"about_ca_system_score_gemma":0.004186588,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.003593834,"about_ca_topic_score_gemma":0.01652407,"domain_scores_codex":[0.9954748,0.0007270283,0.001124717,0.000655677,0.001230098,0.0007876492],"domain_scores_gemma":[0.9973515,0.000504287,0.0001681909,0.0006746516,0.0008880203,0.0004133279],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.01428895,0.001833126,0.8154408,0.0009077794,0.0003675577,0.0003759279,0.004047058,0.0001570214,0.1394646,0.0001951983,0.0119436,0.01097838],"study_design_scores_gemma":[0.06073011,0.003344798,0.8007284,0.003730774,0.0001832958,0.000008164749,0.00628937,0.001028038,0.1029055,0.005629691,0.01431948,0.001102365],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9663246,0.02184895,0.000002486555,0.006688684,0.0002060982,0.001764397,0.0001596452,0.00002055129,0.002984639],"genre_scores_gemma":[0.9910774,0.004731101,0.0004935679,0.00007491542,0.0001885431,0.000828277,0.00005086812,0.00004429282,0.002511033],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.04644116,"threshold_uncertainty_score":0.9220818,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.2777102049017103,"score_gpt":0.5002984513579463,"score_spread":0.222588246456236,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}