{"id":"W2160463964","doi":"10.1158/1078-0432.ccr-14-2666","title":"Androgen Receptor Gene Aberrations in Circulating Cell-Free DNA: Biomarkers of Therapeutic Resistance in Castration-Resistant Prostate Cancer","year":2015,"lang":"en","type":"article","venue":"Clinical Cancer Research","topic":"Prostate Cancer Treatment and Research","field":"Medicine","cited_by":479,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia; BC Cancer Agency","funders":"","keywords":"Prostate cancer; Androgen receptor; Medicine; Cancer research; Prostate; Androgen; Cancer; Castration; Oncology; Internal medicine; Hormone","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003042386,0.0002074089,0.0002471096,0.0008680728,0.0001703884,0.0003325263,0.0002258522,0.0003151621,0.001263441],"category_scores_gemma":[0.001478807,0.0001139351,0.00008476349,0.00054758,0.0003083551,0.0001946384,0.0001583624,0.0002707493,0.0001310973],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002344939,"about_ca_system_score_gemma":0.0001908239,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007100019,"about_ca_topic_score_gemma":0.001024749,"domain_scores_codex":[0.9997019,0.00006029775,0.00002977069,0.00007820758,0.0001016329,0.00002809282],"domain_scores_gemma":[0.9991003,0.0002910678,0.0003660975,0.00004963936,0.00009687139,0.00009600365],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.00127815,0.00009503498,0.8668679,0.0001290141,0.00008263707,0.0007494127,0.0001874569,0.0002774792,0.1029461,0.00006251184,0.0001303588,0.027194],"study_design_scores_gemma":[0.00007101552,0.001246449,0.9654999,0.00002260176,0.00009324324,0.008967698,0.0001656686,0.001002365,0.02190028,0.0001112487,0.0009095484,0.0000100038],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9983552,0.0009360035,0.0004157602,0.00002063878,0.000004391581,0.000008429934,0.000082693,0.0000124627,0.0001644032],"genre_scores_gemma":[0.9992152,0.0001254349,0.0004451253,0.00001662128,0.000006881367,0.000005669783,0.0001008272,0.000001687159,0.00008249749],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001263441,"threshold_uncertainty_score":0.004226625,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.2777102049017103,"score_gpt":0.5002984513579463,"score_spread":0.222588246456236,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}