{"id":"W2160466549","doi":"10.14814/phy2.12008","title":"Multiple signaling pathways regulate contractile activity-mediated PGC-1<i>α</i> gene expression and activity in skeletal muscle cells","year":2014,"lang":"en","type":"article","venue":"Physiological Reports","topic":"Adipose Tissue and Metabolism","field":"Medicine","cited_by":66,"is_retracted":false,"has_abstract":true,"ca_institutions":"York University","funders":"China Scholarship Council; Natural Sciences and Engineering Research Council of Canada; National Natural Science Foundation of China","keywords":"Signal transduction; Cell biology; AMPK; Mitochondrial biogenesis; Myogenesis; Coactivator; Biology; Transcription factor; Calcium signaling; Regulation of gene expression; Phosphorylation; Chemistry; Gene; Mitochondrion; Myocyte; Protein kinase A; Biochemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004479729,0.0002551471,0.0006758008,0.00006434351,0.00009376529,0.00001533772,0.00004782955,0.0002396243,0.00005996219],"category_scores_gemma":[0.0009351756,0.0001870165,0.0001013861,0.0001546802,0.0001133422,0.0001752121,0.0001014856,0.0003968279,0.00001194834],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002913619,"about_ca_system_score_gemma":0.00004106584,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00009510192,"about_ca_topic_score_gemma":0.000004401034,"domain_scores_codex":[0.9981289,0.0001871243,0.0003415009,0.0006515588,0.0002637169,0.0004272089],"domain_scores_gemma":[0.9985663,0.0003985185,0.000293942,0.0003903392,0.00007015619,0.0002807354],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001145298,0.0004137223,0.0008688245,0.0000345809,0.00001255991,0.0004360331,0.00006754452,0.00004233373,0.9824644,0.000003391752,0.00007041146,0.01547161],"study_design_scores_gemma":[0.0008567,0.0001545078,0.3835147,0.00006550021,0.00003087681,0.00004903036,0.000009398415,0.0006525892,0.6115892,0.0003207312,0.002570301,0.0001864725],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9983354,0.0001896247,0.0003620377,0.00007527479,0.0001856975,0.0004502363,0.000006174219,0.0001113716,0.0002842287],"genre_scores_gemma":[0.9986616,0.0001194665,0.0006103985,0.0001615052,0.000267083,0.00003726316,0.00003202016,0.00002452605,0.00008613591],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.3826459,"threshold_uncertainty_score":0.762631,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02503607672699085,"score_gpt":0.2551507865748533,"score_spread":0.2301147098478625,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}