{"id":"W2160580412","doi":"10.1016/j.carres.2008.12.007","title":"Structural insight into the mechanism of streptozotocin inhibition of O-GlcNAcase","year":2008,"lang":"en","type":"article","venue":"Carbohydrate Research","topic":"Glycosylation and Glycoproteins Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":25,"is_retracted":false,"has_abstract":false,"ca_institutions":"Simon Fraser University","funders":"Biotechnology and Biological Sciences Research Council","keywords":"Chemistry; Streptozotocin; Bacteroides thetaiotaomicron; Cytotoxicity; Mechanism (biology); Biochemistry; Islet; Diabetes mellitus; Stereochemistry; Cell biology; Bacteroides; Endocrinology; In vitro; Genetics; Bacteria; Biology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0007116977,0.0001046523,0.0001467113,0.0001851157,0.0002241673,0.00001053404,0.0002561371,0.000141396,0.00007902145],"category_scores_gemma":[0.0003184062,0.0000753489,0.00008861272,0.0005209768,0.0005444408,0.000006945541,0.0002573493,0.0002687854,0.00000929317],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0000250379,"about_ca_system_score_gemma":0.0002671339,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004107926,"about_ca_topic_score_gemma":0.00008458934,"domain_scores_codex":[0.9980957,0.0003864969,0.0002809449,0.000263171,0.0006761164,0.0002975975],"domain_scores_gemma":[0.9985294,0.00004765336,0.00007321242,0.0005151965,0.0007421833,0.00009237104],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001095037,0.00002753213,0.0003412527,0.0000366397,0.00002371927,0.00001393273,0.000657782,0.00003405326,0.9956535,0.002214958,0.0001765761,0.0007106055],"study_design_scores_gemma":[0.0004140738,0.0003509739,0.0005836109,0.00001565158,0.000002465462,0.00001091967,0.0002061276,0.0004843962,0.9960994,0.000966652,0.0007887445,0.0000770422],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9972073,0.0004022134,0.00008657177,0.0002033426,0.00003707776,0.0005136186,0.00001209135,0.000004803011,0.001532985],"genre_scores_gemma":[0.9989406,0.0002660859,0.0001036454,0.00001653832,0.00008659027,0.00005534667,0.00005811912,0.0000166912,0.0004563507],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001733336,"threshold_uncertainty_score":0.3072639,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04687898117288852,"score_gpt":0.3291481074867812,"score_spread":0.2822691263138927,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}