{"id":"W2160597466","doi":"10.1002/ana.23650","title":"Amyloid deposition, hypometabolism, and longitudinal cognitive decline","year":2012,"lang":"en","type":"article","venue":"Annals of Neurology","topic":"Dementia and Cognitive Impairment Research","field":"Medicine","cited_by":753,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"National Institute on Aging; Avid Radiopharmaceuticals; University of California, San Diego; National Institute of Biomedical Imaging and Bioengineering; Canadian Institutes of Health Research; University of California, Los Angeles; National Institutes of Health; Servier; Elan; Astellas Pharma; Eisai; Genentech; University of Oxford; Northern California Institute for Research and Education; Pfizer; Biogen; BioClinica; Alzheimer's Association; Amorfix Life Sciences; Dana Foundation; Bayer HealthCare; Alzheimer's Disease Neuroimaging Initiative; Meso Scale Diagnostics; F. Hoffmann-La Roche; Medpace; AstraZeneca; Eli Lilly and Company; Bristol-Myers Squibb; Novartis Pharmaceuticals Corporation; Amgen; Synarc; Foundation for the National Institutes of Health","keywords":"Cognitive decline; Neuroimaging; Positron emission tomography; Cognition; Internal medicine; Subclinical infection; Alzheimer's disease; Cog; Psychology; Medicine; Longitudinal study; Fluorodeoxyglucose; Dementia; Disease; Endocrinology; Pathology; Neuroscience","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001020485,0.0003970539,0.0002385128,0.0006497229,0.0002590352,0.0004458846,0.0002293289,0.0002737394,0.0006771932],"category_scores_gemma":[0.002674606,0.0001995683,0.0001955221,0.0005087798,0.0002120232,0.0003636929,0.0002886656,0.0003596098,0.0001313411],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001821694,"about_ca_system_score_gemma":0.0001990455,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002332178,"about_ca_topic_score_gemma":0.003879131,"domain_scores_codex":[0.999787,0.00006083522,0.0000242568,0.00006296094,0.0000406831,0.00002420054],"domain_scores_gemma":[0.998425,0.0002042743,0.0009341399,0.00009255519,0.0001800175,0.0001641522],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0001653316,0.00002320771,0.998288,0.000006374322,0.00005371781,0.00004133932,0.00003830916,0.00002707952,0.0003329226,0.000005055977,0.00002194885,0.0009968483],"study_design_scores_gemma":[0.000003641664,0.00006513707,0.9994599,0.000002388202,0.00001430057,0.0002345314,0.00001515257,0.00007442144,0.0000743515,0.00001227772,0.00004285291,9.258992e-7],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9993516,0.0003209277,0.00004415916,0.00001699661,0.000001567378,0.000002905017,0.0001158096,0.00000292302,0.0001432328],"genre_scores_gemma":[0.9994162,0.0001039781,0.000108984,0.00001531342,0.000008867149,0.000005050066,0.0002561645,0.000001006733,0.00008450099],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002332178,"threshold_uncertainty_score":0.005396962,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0672543484257386,"score_gpt":0.3794653467977199,"score_spread":0.3122109983719813,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}