{"id":"W2160620965","doi":"10.1074/jbc.m114.609644","title":"Crystal Structure of the Middle East Respiratory Syndrome Coronavirus (MERS-CoV) Papain-like Protease Bound to Ubiquitin Facilitates Targeted Disruption of Deubiquitinating Activity to Demonstrate Its Role in Innate Immune Suppression","year":2014,"lang":"en","type":"article","venue":"Journal of Biological Chemistry","topic":"interferon and immune responses","field":"Immunology and Microbiology","cited_by":160,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Manitoba","funders":"Nederlandse Organisatie voor Wetenschappelijk Onderzoek; Canadian Institutes of Health Research; Natural Sciences and Engineering Research Council of Canada; European Commission; Research Manitoba; Canadian Light Source","keywords":"Deubiquitinating enzyme; Middle East respiratory syndrome coronavirus; Protease; Biology; Innate immune system; Proteases; Ubiquitin; Coronavirus; Virology; Papain; Immune system; Cell biology; Gene; Biochemistry; Enzyme; Genetics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0007121515,0.0002321969,0.0005726521,0.00008120481,0.00009974501,0.00001220312,0.0004432208,0.0003805298,0.0001701674],"category_scores_gemma":[0.001225929,0.0001473971,0.0001968335,0.0001705434,0.0002522217,0.00009003693,0.0002353995,0.0006627882,0.000004370398],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00008413057,"about_ca_system_score_gemma":0.0000976851,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00002032591,"about_ca_topic_score_gemma":0.000004116502,"domain_scores_codex":[0.9978198,0.0006862111,0.0008286429,0.0002277752,0.0000985984,0.0003389674],"domain_scores_gemma":[0.9986091,0.0002178199,0.0006875993,0.0002232168,0.0002099006,0.00005240489],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.002577132,0.0001928819,0.001945642,0.0001047075,0.00005051008,0.000006148428,0.0004669553,0.00002952136,0.9932942,0.000003435101,0.00001117865,0.001317692],"study_design_scores_gemma":[0.0008077964,0.001006369,0.03473455,0.0004528718,0.00001405231,0.0001618513,0.0009652945,0.000005334356,0.9612181,0.00004197904,0.0004350127,0.0001568164],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9983734,0.0008741874,0.00002561006,0.00008955173,0.0001625813,0.000272191,0.000143753,0.000009159029,0.00004949491],"genre_scores_gemma":[0.9997609,0.000004951319,0.00004347303,0.00006865583,0.00001714459,0.000006858512,0.000007535486,0.000009668486,0.0000808082],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.03278891,"threshold_uncertainty_score":0.6010681,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03118128005313754,"score_gpt":0.2634956566169801,"score_spread":0.2323143765638426,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}