{"id":"W2160667218","doi":"10.1124/jpet.109.164871","title":"Heme Arginate Therapy Enhanced Adiponectin and Atrial Natriuretic Peptide, but Abated Endothelin-1 with Attenuation of Kidney Histopathological Lesions in Mineralocorticoid-Induced Hypertension","year":2010,"lang":"en","type":"article","venue":"Journal of Pharmacology and Experimental Therapeutics","topic":"Heme Oxygenase-1 and Carbon Monoxide","field":"Biochemistry, Genetics and Molecular Biology","cited_by":25,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Saskatchewan","funders":"Canadian Institutes of Health Research","keywords":"Medicine; Adiponectin; Internal medicine; Atrial natriuretic peptide; Endothelin receptor; Aldosterone; Mineralocorticoid receptor; Endocrinology; Kidney; Cardiology; Receptor","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001989663,0.0005396293,0.0009700643,0.0002240425,0.0002786341,0.0003295841,0.00031186,0.0004934453,0.002198132],"category_scores_gemma":[0.0002100406,0.0002544675,0.000271472,0.0001511042,0.0006793814,0.0004866104,0.0001746998,0.001800931,0.0002629175],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002344497,"about_ca_system_score_gemma":0.000407705,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005409977,"about_ca_topic_score_gemma":0.001164718,"domain_scores_codex":[0.9998059,0.00003522739,0.00002145589,0.00003951546,0.00003449859,0.00006351552],"domain_scores_gemma":[0.9998079,0.00002323854,0.00003755237,0.00002447038,0.00001737183,0.00008944108],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.008036912,0.0005951679,0.0001910048,0.00007403392,0.00001874945,0.000172754,0.00003334184,0.00005395434,0.9867685,0.0001488315,0.0001142388,0.003792489],"study_design_scores_gemma":[0.0008569101,0.006591226,0.007984497,0.000008945657,0.0001239714,0.0005320141,0.00009166846,0.001033012,0.9801745,0.0002358237,0.002346526,0.00002084465],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9945191,0.0008819578,0.002828638,0.0003392554,0.00018225,0.00004827873,0.0001726769,0.0002179735,0.0008098145],"genre_scores_gemma":[0.9955959,0.0003629703,0.001378214,0.00007425146,0.00004320125,0.0000421029,0.0001206982,0.00001953779,0.002363211],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002198132,"threshold_uncertainty_score":0.007353485,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02068884084483436,"score_gpt":0.2954838097337201,"score_spread":0.2747949688888858,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}