{"id":"W2160688613","doi":"10.1186/bcr2347","title":"The cytotoxicity of γ-secretase inhibitor I to breast cancer cells is mediated by proteasome inhibition, not by γ-secretase inhibition","year":2009,"lang":"en","type":"article","venue":"Breast Cancer Research","topic":"Ubiquitin and proteasome pathways","field":"Biochemistry, Genetics and Molecular Biology","cited_by":70,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Alberta","funders":"Canadian Institutes of Health Research; Fondation pour la Recherche Médicale; Alberta Cancer Foundation; Cancer Research Institute","keywords":"Cytotoxicity; Breast cancer; Cancer research; Surgical oncology; Proteasome inhibitor; Medicine; Proteasome; Chemistry; Cancer; Internal medicine; In vitro; Biochemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.001326435,0.0003675413,0.0003324548,0.000138247,0.0005090966,0.0001257189,0.0004179351,0.0003287481,0.0004647145],"category_scores_gemma":[0.00009191467,0.0002988553,0.0001565599,0.0006880585,0.0003983371,0.00002860282,0.0002444898,0.0005371075,0.00005912655],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001981829,"about_ca_system_score_gemma":0.0005940837,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001454545,"about_ca_topic_score_gemma":0.0001966243,"domain_scores_codex":[0.9959542,0.0004703325,0.0005677241,0.0008459936,0.001151143,0.001010568],"domain_scores_gemma":[0.9975315,0.00006190041,0.0001966932,0.0006898073,0.0009707588,0.0005492851],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001351943,0.0002060235,0.0002228192,0.00005926633,0.0000430967,0.000004888803,0.0001013774,0.000004863809,0.8523376,0.00002129953,0.1405773,0.005069519],"study_design_scores_gemma":[0.001160063,0.0004051168,0.001408878,0.0001879567,0.00001370493,0.00003271513,0.00007973698,0.00002280377,0.9781321,0.00007024598,0.01812633,0.0003604048],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9566895,0.001824134,0.00007661447,0.01517431,0.0001029403,0.001975071,0.02391774,0.0000341668,0.0002054933],"genre_scores_gemma":[0.9938895,0.00120034,0.0000308139,0.001941258,0.0005802998,0.0009733647,0.0006731636,0.00005542157,0.0006558487],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1257945,"threshold_uncertainty_score":0.9999464,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02006290190402402,"score_gpt":0.3131353047738517,"score_spread":0.2930724028698276,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}