{"id":"W2160688613","doi":"10.1186/bcr2347","title":"The cytotoxicity of γ-secretase inhibitor I to breast cancer cells is mediated by proteasome inhibition, not by γ-secretase inhibition","year":2009,"lang":"en","type":"article","venue":"Breast Cancer Research","topic":"Ubiquitin and proteasome pathways","field":"Biochemistry, Genetics and Molecular Biology","cited_by":70,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Alberta","funders":"Canadian Institutes of Health Research; Fondation pour la Recherche Médicale; Alberta Cancer Foundation; Cancer Research Institute","keywords":"Cytotoxicity; Breast cancer; Cancer research; Surgical oncology; Proteasome inhibitor; Medicine; Proteasome; Chemistry; Cancer; Internal medicine; In vitro; Biochemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001776326,0.0005266628,0.0004430041,0.0002248019,0.0001398729,0.0003358952,0.0002758698,0.0002063506,0.001540794],"category_scores_gemma":[0.0001379052,0.0001223469,0.0003842181,0.0002899203,0.0001741117,0.0001659693,0.0001249517,0.0005414493,0.0005372195],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003459933,"about_ca_system_score_gemma":0.0003518709,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006136508,"about_ca_topic_score_gemma":0.0007524058,"domain_scores_codex":[0.9998007,0.00002617415,0.00003553887,0.00004284926,0.00005431241,0.00004044216],"domain_scores_gemma":[0.9998575,0.00002780298,0.00004472193,0.00003076878,0.00002135301,0.00001787797],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003063306,0.0001234607,0.0003480496,0.0001056797,0.00002347313,0.00005091738,0.00001684071,0.0001222448,0.9948172,0.00006758916,0.00012423,0.003894027],"study_design_scores_gemma":[0.00002893834,0.0004683547,0.001750882,0.000005975752,0.00001882432,0.0001446876,0.000008378935,0.0002949229,0.9959276,0.00001204089,0.001336949,0.000002323097],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9822568,0.007092734,0.002822526,0.0001458013,0.00007631475,0.000124964,0.001281437,0.0002208266,0.005978605],"genre_scores_gemma":[0.9888597,0.003302457,0.002498381,0.0000802246,0.00001610379,0.0001286059,0.00204393,0.00002444888,0.003046148],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001540794,"threshold_uncertainty_score":0.005154431,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02006290190402402,"score_gpt":0.3131353047738517,"score_spread":0.2930724028698276,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}