{"id":"W2160694221","doi":"10.1158/1535-7163.mct-09-0673","title":"Subcellular Distribution of a Fluorescence-Labeled Combi-Molecule Designed to Block Epidermal Growth Factor Receptor Tyrosine Kinase and Damage DNA with a Green Fluorescent Species","year":2010,"lang":"en","type":"article","venue":"Molecular Cancer Therapeutics","topic":"Cancer therapeutics and mechanisms","field":"Biochemistry, Genetics and Molecular Biology","cited_by":19,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University; Royal Victoria Hospital","funders":"National Cancer Institute; McGill University Health Centre","keywords":"Biology; Epidermal growth factor receptor; Molecular biology; DNA damage; Kinase; Tyrosine kinase; Transfection; DNA repair; Phosphorylation; DNA; Cell biology; Biochemistry; Signal transduction; Receptor; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.000148439,0.000423215,0.000388605,0.00007576733,0.0001271941,0.00005533975,0.0003436453,0.000237461,0.00003635739],"category_scores_gemma":[0.00001670039,0.0003845417,0.0001205187,0.0002852262,0.0002269218,0.000009656874,0.0001537663,0.0002366884,0.000002435411],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00004767576,"about_ca_system_score_gemma":0.0001890512,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001661963,"about_ca_topic_score_gemma":0.0002128831,"domain_scores_codex":[0.9980369,0.000095752,0.0003567444,0.0006220607,0.0003716924,0.0005168067],"domain_scores_gemma":[0.9985544,0.00001361442,0.0001824742,0.0006131585,0.0003768931,0.0002594379],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0007158782,0.0001779896,0.0008415395,0.00006276943,0.0002485102,0.00001504972,0.0001643513,0.00001093162,0.994539,0.0009723278,0.00005373416,0.002197944],"study_design_scores_gemma":[0.001741558,0.001093653,0.001614552,0.00005244888,0.0001506116,0.0000119327,0.00004092187,0.0001117369,0.9844901,0.00006057683,0.01013548,0.0004964136],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9847427,0.0009907694,0.01192501,0.000945705,0.0002161867,0.0007184052,0.0004077239,0.00002682715,0.0000266702],"genre_scores_gemma":[0.9956364,0.0004622545,0.002275751,0.0009288464,0.0001334601,0.00009144255,0.0002323902,0.0000867979,0.0001526395],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01089371,"threshold_uncertainty_score":0.9998606,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01278670995869844,"score_gpt":0.2381801193780552,"score_spread":0.2253934094193568,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}