{"id":"W2160712617","doi":"10.1152/ajpheart.01328.2005","title":"Downregulation of NADPH oxidase, antioxidant enzymes, and inflammatory markers in the heart of streptozotocin-induced diabetic rats by <i>N</i>-acetyl-<scp>l</scp>-cysteine","year":2006,"lang":"en","type":"article","venue":"American Journal of Physiology-Heart and Circulatory Physiology","topic":"Heme Oxygenase-1 and Carbon Monoxide","field":"Biochemistry, Genetics and Molecular Biology","cited_by":97,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia","funders":"Shanxi Medical University; National Institutes of Health; Shanxi University","keywords":"Nicotinamide adenine dinucleotide phosphate; NADPH oxidase; Streptozotocin; Superoxide dismutase; Endocrinology; Oxidative stress; Internal medicine; Chemistry; Diabetic cardiomyopathy; Antioxidant; Heme oxygenase; Reactive oxygen species; Superoxide; NAD(P)H oxidase; Oxidase test; Nicotinamide; Diabetes mellitus; Enzyme; Biochemistry; Medicine; Heme; Heart failure","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0005302017,0.0002650452,0.0007397563,0.00012264,0.00005880346,0.000006851194,0.0001939747,0.0001647144,0.000003614332],"category_scores_gemma":[0.00006348472,0.0002110867,0.0001847186,0.0001981578,0.0008183094,0.00001983149,0.00006473996,0.0002321702,5.053332e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001375621,"about_ca_system_score_gemma":0.0001219185,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00009257549,"about_ca_topic_score_gemma":0.00001238954,"domain_scores_codex":[0.9977947,0.0005667392,0.0007456216,0.0003713258,0.0001762364,0.0003453857],"domain_scores_gemma":[0.9985572,0.0001557775,0.0006883637,0.0003639038,0.000141776,0.0000929803],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.00009602715,0.0001272677,0.007063042,0.00005902294,0.00008312696,4.741058e-7,0.00007703033,0.00007360754,0.9911408,0.00005158601,0.001114271,0.0001137892],"study_design_scores_gemma":[0.0006702871,0.001245145,0.6665875,0.00003466934,0.00003327679,0.00004042115,0.0004929489,0.00002067604,0.3297753,0.0001539903,0.0008488459,0.00009695562],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.997686,0.001906296,0.000002136739,0.00006256623,0.00005961482,0.0002219689,0.00001759055,0.000003840637,0.00003994921],"genre_scores_gemma":[0.9992522,0.0001305661,0.00007761758,0.0003027863,0.0001640324,0.00001187704,0.00002873493,0.00002231955,0.00000983714],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.6613654,"threshold_uncertainty_score":0.8607864,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.004246196405009279,"score_gpt":0.2070241380395817,"score_spread":0.2027779416345724,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}