{"id":"W2160716257","doi":"10.1091/mbc.e08-01-0019","title":"Casein Kinase 2 Binds to the C Terminus of Na<sup>+</sup>/H<sup>+</sup>exchanger 3 (NHE3) and Stimulates NHE3 Basal Activity by Phosphorylating a Separate Site in NHE3","year":2008,"lang":"en","type":"article","venue":"Molecular Biology of the Cell","topic":"Ion Transport and Channel Regulation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":56,"is_retracted":false,"has_abstract":true,"ca_institutions":"Western University","funders":"National Center for Research Resources; National Institute of Diabetes and Digestive and Kidney Diseases; National Institutes of Health; Johns Hopkins University","keywords":"Phosphorylation; Sodium–hydrogen antiporter; Biology; Molecular biology; Kinase; Casein kinase 2; Autophosphorylation; Phosphatase; Exocytosis; Cell biology; Biochemistry; Protein kinase A; Chemistry; Mitogen-activated protein kinase kinase; Secretion","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003356902,0.0003208503,0.0003823365,0.00008945162,0.0001464293,0.000007791278,0.0003330077,0.0003601672,0.00001768875],"category_scores_gemma":[0.00003797288,0.0002336273,0.0001960433,0.0002528563,0.0003427418,0.000008338166,0.0001889384,0.0001977154,0.000004324574],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002059321,"about_ca_system_score_gemma":0.00006382177,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002394198,"about_ca_topic_score_gemma":0.00002862399,"domain_scores_codex":[0.9982727,0.0002635224,0.0003846222,0.0005190708,0.000153384,0.0004067664],"domain_scores_gemma":[0.9990139,0.00003662212,0.0002087827,0.0005559015,0.00009376851,0.00009104166],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003187768,0.0001384965,0.01155718,0.00004893612,0.00005162491,0.00002732884,0.0009580139,0.01321515,0.9722068,0.000004213936,0.000487065,0.0009863967],"study_design_scores_gemma":[0.001016079,0.000355463,0.00300485,0.00003169957,0.00004535581,0.00002511109,0.0001222228,0.0074947,0.9855717,0.00003489211,0.002013794,0.0002841284],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9964104,0.001455945,0.0008743395,0.0004660485,0.00007227325,0.0004728552,0.0001484375,0.000008795576,0.00009088728],"genre_scores_gemma":[0.9986125,0.0001163079,0.0001681281,0.0003109782,0.00007214996,0.00003114631,0.0001664531,0.00003533929,0.0004870607],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01336489,"threshold_uncertainty_score":0.9527044,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.007498292274170701,"score_gpt":0.227452910439306,"score_spread":0.2199546181651353,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}