{"id":"W2160716257","doi":"10.1091/mbc.e08-01-0019","title":"Casein Kinase 2 Binds to the C Terminus of Na<sup>+</sup>/H<sup>+</sup>exchanger 3 (NHE3) and Stimulates NHE3 Basal Activity by Phosphorylating a Separate Site in NHE3","year":2008,"lang":"en","type":"article","venue":"Molecular Biology of the Cell","topic":"Ion Transport and Channel Regulation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":56,"is_retracted":false,"has_abstract":true,"ca_institutions":"Western University","funders":"National Center for Research Resources; National Institute of Diabetes and Digestive and Kidney Diseases; National Institutes of Health; Johns Hopkins University","keywords":"Phosphorylation; Sodium–hydrogen antiporter; Biology; Molecular biology; Kinase; Casein kinase 2; Autophosphorylation; Phosphatase; Exocytosis; Cell biology; Biochemistry; Protein kinase A; Chemistry; Mitogen-activated protein kinase kinase; Secretion","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001340431,0.0005517824,0.0003050998,0.0001564541,0.0002047106,0.0002514693,0.0002000362,0.0003038137,0.00290691],"category_scores_gemma":[0.0001212398,0.0002101562,0.0004672071,0.0001765201,0.0002280913,0.000165773,0.0001941356,0.0004985223,0.0008656094],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005292385,"about_ca_system_score_gemma":0.0002171991,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007965059,"about_ca_topic_score_gemma":0.0007743362,"domain_scores_codex":[0.9998426,0.00001717289,0.00001253724,0.00005057772,0.00003201624,0.00004499681],"domain_scores_gemma":[0.9999191,0.00001056531,0.00002789098,0.000006777953,0.000009344133,0.00002640413],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001921434,0.00001746165,0.0003757038,0.00005229541,0.00001350884,0.000052236,0.000004783127,0.00004162914,0.9985018,0.00005019565,0.00009343324,0.0006049949],"study_design_scores_gemma":[0.00005268104,0.0001711911,0.02324598,0.00001087893,0.00003465549,0.0006243241,0.00002398427,0.001613177,0.9695925,0.00008036094,0.004539294,0.00001093353],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9850991,0.004759273,0.005716268,0.0002548139,0.0001625622,0.0000456036,0.001087197,0.0001057553,0.00276957],"genre_scores_gemma":[0.9864712,0.001663792,0.004232349,0.0002046877,0.00006264109,0.00005871525,0.002864357,0.00003139281,0.004410825],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00290691,"threshold_uncertainty_score":0.009724617,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.007498292274170701,"score_gpt":0.227452910439306,"score_spread":0.2199546181651353,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}