{"id":"W2160761735","doi":"10.1186/1476-511x-7-22","title":"Plasma PCSK9 levels are significantly modified by statins and fibrates in humans","year":2008,"lang":"en","type":"article","venue":"Lipids in Health and Disease","topic":"Lipoproteins and Cardiovascular Health","field":"Medicine","cited_by":217,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Ottawa; Queen's University; Ottawa Hospital","funders":"Canadian Stroke Network; Canadian Institutes of Health Research; University of Ottawa","keywords":"PCSK9; Fenofibrate; LDL receptor; Internal medicine; Endocrinology; Kexin; Lipidology; HMG-CoA reductase; Cholesterol; Clinical chemistry; Atorvastatin; Gemfibrozil; Lipoprotein; Medicine; Biology; Chemistry; Reductase; Biochemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004062102,0.0001671949,0.000462,0.000130408,0.0001696073,0.00001309416,0.00003879771,0.00006694436,0.00001713865],"category_scores_gemma":[0.0002661025,0.0001482103,0.00005035075,0.0001810309,0.0001048782,0.00008313412,0.00002637659,0.0002531005,0.000002415234],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00006849965,"about_ca_system_score_gemma":0.0007194621,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001046512,"about_ca_topic_score_gemma":0.0001754238,"domain_scores_codex":[0.9983045,0.0001815331,0.000420779,0.0003887727,0.0002608738,0.0004435485],"domain_scores_gemma":[0.9981135,0.00007443771,0.00008006675,0.0002706395,0.00002454818,0.001436802],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0015125,0.0006836656,0.9612725,0.005657075,0.00003549038,0.0004197778,0.004561447,0.00006619174,0.00006327454,0.0005654747,0.004738164,0.02042444],"study_design_scores_gemma":[0.008609468,0.0006415343,0.9798208,0.0007397544,0.00002223944,0.00002747519,0.002018309,0.001857397,0.00003853986,0.0006342526,0.005235498,0.0003547295],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9879946,0.008140815,0.00007005459,0.002570993,0.00006217608,0.0008203565,0.0001739181,0.00003200786,0.0001350412],"genre_scores_gemma":[0.9938238,0.002479197,0.0001846677,0.003033927,0.0001411249,0.00007611579,0.00005578605,0.00001948325,0.0001858498],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.02006971,"threshold_uncertainty_score":0.6043841,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03716039431697274,"score_gpt":0.2858031226837593,"score_spread":0.2486427283667866,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}