{"id":"W2160790523","doi":"10.1371/journal.pone.0013592","title":"Obtaining Valid Laboratory Data in Clinical Trials Conducted in Resource Diverse Settings: Lessons Learned from a Microbicide Phase III Clinical Trial","year":2010,"lang":"en","type":"article","venue":"PLoS ONE","topic":"Bacterial Identification and Susceptibility Testing","field":"Biochemistry, Genetics and Molecular Biology","cited_by":12,"is_retracted":false,"has_abstract":true,"ca_institutions":"Centre hospitalier universitaire de Québec; Université Laval","funders":"Bill and Melinda Gates Foundation; United States Agency for International Development","keywords":"Microbicide; Medicine; Quality assurance; Microbicides for sexually transmitted diseases; Clinical trial; Medical physics; Chlamydia trachomatis; Quality control; Human immunodeficiency virus (HIV); Family medicine; Environmental health; Gynecology; Control (management); External quality assessment; Computer science; Population; Pathology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaresearch"],"consensus_categories":[],"category_scores_codex":[0.01582817,0.0001886526,0.0008369238,0.00008010132,0.00007242052,0.00009281863,0.0006692609,0.0005550814,0.0001171191],"category_scores_gemma":[0.04924912,0.0001991684,0.0001252972,0.0002053807,0.0002058721,0.00001679424,0.0004978746,0.0008764135,0.000021825],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001347568,"about_ca_system_score_gemma":0.0003524948,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001629545,"about_ca_topic_score_gemma":0.001177359,"domain_scores_codex":[0.9932046,0.002957801,0.002262288,0.001089792,0.0001832291,0.0003022669],"domain_scores_gemma":[0.9962369,0.001252021,0.0006702555,0.00151954,0.0001502338,0.0001710693],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.009012409,0.00343346,0.00960576,0.00001091638,0.000123689,0.000009167362,0.00009809998,2.240291e-7,0.9713035,0.000004175075,0.00092633,0.005472239],"study_design_scores_gemma":[0.4909402,0.002327373,0.02854567,0.0007106147,0.001028777,0.000002859138,0.002951208,0.001483678,0.4066702,0.0002556261,0.06297856,0.002105233],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.996791,0.00004725204,0.00001588078,0.001313393,0.0004708648,0.0006911252,0.0005898231,0.00003374559,0.00004688423],"genre_scores_gemma":[0.9913374,0.00008172404,0.002742967,0.0006467818,0.001751183,0.00002360014,0.003278617,0.00003008895,0.0001076422],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.5646333,"threshold_uncertainty_score":0.9587594,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.4897092579988105,"score_gpt":0.4836436839304854,"score_spread":0.006065574068325086,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}