{"id":"W2160846997","doi":"10.1158/1535-7163.mct-12-0227","title":"First Evidence of Sphingosine 1-Phosphate Lyase Protein Expression and Activity Downregulation in Human Neoplasm: Implication for Resistance to Therapeutics in Prostate Cancer","year":2012,"lang":"en","type":"article","venue":"Molecular Cancer Therapeutics","topic":"Sphingolipid Metabolism and Signaling","field":"Biochemistry, Genetics and Molecular Biology","cited_by":68,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Institute of Cancer Research; Ligue Contre le Cancer; Institut National Du Cancer; Association pour la Recherche sur le Cancer","keywords":"Ceramide; Sphingosine kinase 1; Prostate cancer; Sphingosine; Cancer; Cancer cell; Cancer research; Sphingosine kinase; Sphingosine-1-phosphate; Gene silencing; Apoptosis; Biology; Medicine; Internal medicine; Biochemistry","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001355072,0.0002352147,0.0002430708,0.0003158058,0.0001132157,0.0003022066,0.0001175986,0.0002717929,0.001257828],"category_scores_gemma":[0.0001873192,0.00009542974,0.0002343815,0.0002301264,0.0002357518,0.0001403098,0.0002077228,0.0004904051,0.0003327023],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001763089,"about_ca_system_score_gemma":0.0002381302,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004174953,"about_ca_topic_score_gemma":0.0005126352,"domain_scores_codex":[0.9998987,0.00001467069,0.00000825445,0.00002477676,0.00003379181,0.00001991985],"domain_scores_gemma":[0.999806,0.00004675121,0.00004615775,0.00002734521,0.00003903217,0.0000348225],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003494264,0.00005253996,0.005426476,0.0001910513,0.00002648729,0.0003510273,0.00003921608,0.00006341095,0.9809002,0.0001133953,0.0003073847,0.01217946],"study_design_scores_gemma":[0.00002013192,0.001275142,0.08644603,0.00001804223,0.0001060805,0.004792302,0.00008395877,0.0007304534,0.8868619,0.0001531571,0.0194989,0.0000139214],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9526398,0.03055505,0.01015586,0.0006988733,0.00009300998,0.00009762414,0.001119879,0.0004106048,0.004229337],"genre_scores_gemma":[0.9875314,0.006653054,0.002355068,0.0001744233,0.00004816718,0.00003836569,0.001015635,0.00002360628,0.002160165],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001257828,"threshold_uncertainty_score":0.004207909,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02847316134798622,"score_gpt":0.3228567867164746,"score_spread":0.2943836253684884,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}