{"id":"W2160873422","doi":"10.1074/jbc.m102101200","title":"Structure of the Pore-forming Transmembrane Domain of a Ligand-gated Ion Channel","year":2001,"lang":"en","type":"article","venue":"Journal of Biological Chemistry","topic":"Nicotinic Acetylcholine Receptors Study","field":"Biochemistry, Genetics and Molecular Biology","cited_by":33,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Ottawa","funders":"National Institute of Neurological Disorders and Stroke","keywords":"Ion channel; Transmembrane domain; Transmembrane protein; Domain (mathematical analysis); Ligand-gated ion channel; Ion; Biophysics; Channel (broadcasting); Materials science; Chemistry; Ligand (biochemistry); Light-gated ion channel; Crystallography; Membrane; Computer science; Biochemistry; Biology; Receptor; Telecommunications; Mathematics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002411316,0.000159129,0.0003521669,0.00001504958,0.00003698971,0.000003762501,0.0004272744,0.000328465,0.00004860878],"category_scores_gemma":[0.0001866927,0.00008887592,0.0003047578,0.0001497133,0.0001829061,0.000003488375,0.0000919602,0.0002730146,1.332811e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001381007,"about_ca_system_score_gemma":0.00007381215,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000002078508,"about_ca_topic_score_gemma":0.000001029695,"domain_scores_codex":[0.998804,0.00005166996,0.0006119787,0.0001553868,0.000191126,0.000185794],"domain_scores_gemma":[0.9988374,0.00002358953,0.0006616758,0.0002192389,0.0001856567,0.00007247597],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002889853,0.0001163649,0.002532173,0.00003735249,0.00008371969,0.000001695965,0.00004748909,0.00003456054,0.9964249,0.000001870754,0.00009814865,0.000332786],"study_design_scores_gemma":[0.0009058801,0.0002743839,0.0007179566,0.00005985011,0.00002561518,0.0003560118,0.0001918354,0.000003501395,0.9956608,0.000121329,0.00158206,0.0001007794],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9984004,0.000746436,0.0001578898,0.0001757045,0.0001060238,0.00008147013,0.00002315373,0.000002600249,0.0003063251],"genre_scores_gemma":[0.9989217,0.0003652767,0.0002335696,0.00004453551,0.0003398834,4.389052e-7,0.00001593605,0.000009304551,0.00006934206],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001814216,"threshold_uncertainty_score":0.3624255,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0109532783315626,"score_gpt":0.2427404111529703,"score_spread":0.2317871328214078,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}