{"id":"W2160877491","doi":"10.1093/glycob/cwv031","title":"Chemoenzymatic Synthesis of a Type 2 Blood Group A Tetrasaccharide and Development of High-throughput Assays Enables a Platform for Screening Blood Group Antigen-cleaving Enzymes","year":2015,"lang":"en","type":"article","venue":"Glycobiology","topic":"Glycosylation and Glycoproteins Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":21,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia Hospital; University of British Columbia","funders":"Canadian Institutes of Health Research","keywords":"Tetrasaccharide; Enzyme; Chemistry; Biochemistry; Oligosaccharide; Antigen; Glycoside; Glycosylation; High-throughput screening; Glycosyltransferase; Stereochemistry; Biology; Immunology; Polysaccharide","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0007533265,0.0002239631,0.0004478443,0.0001422975,0.0000995213,0.00001515889,0.0002479812,0.0002861157,0.00002206232],"category_scores_gemma":[0.0009026835,0.0002018885,0.00007025472,0.0001565564,0.0001883822,0.00001344621,0.0002442802,0.00009904405,0.000002354405],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001148459,"about_ca_system_score_gemma":0.0001810507,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001383702,"about_ca_topic_score_gemma":0.0001457158,"domain_scores_codex":[0.9983702,0.00007132463,0.0005347029,0.0004355241,0.0001711172,0.0004171031],"domain_scores_gemma":[0.9989073,0.0001427685,0.0002460105,0.0003027761,0.0002689718,0.0001321558],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0007199648,0.0003296127,0.005680946,0.0003351041,0.0005372376,0.000004905854,0.0003479438,0.0000149454,0.9773166,0.001086285,0.0002517363,0.01337475],"study_design_scores_gemma":[0.002270807,0.001181814,0.002404007,0.00009307689,0.00007336321,0.00006138019,0.0004515984,0.000105624,0.9883735,0.0002462619,0.004459542,0.00027901],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9884926,0.00161482,0.009078786,0.00003681903,0.00008859289,0.000512813,0.00004549479,0.00001625813,0.00011381],"genre_scores_gemma":[0.9452229,0.0001407983,0.05419443,0.00003200343,0.00008271192,0.00008937245,0.0001575392,0.0000282258,0.00005197325],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.04511565,"threshold_uncertainty_score":0.8232774,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03699573190060634,"score_gpt":0.2723827148395886,"score_spread":0.2353869829389822,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}