{"id":"W2160889671","doi":"10.1128/aac.04274-14","title":"The R262K Substitution Combined with H51Y in HIV-1 Subtype B Integrase Confers Low-Level Resistance against Dolutegravir","year":2014,"lang":"en","type":"article","venue":"Antimicrobial Agents and Chemotherapy","topic":"HIV/AIDS drug development and treatment","field":"Medicine","cited_by":11,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University; Jewish General Hospital","funders":"Fonds de Recherche du Québec - Santé; Canadian Institutes of Health Research","keywords":"Integrase; Dolutegravir; Integrase inhibitor; Mutant; Virology; Recombinant DNA; Biology; Viral replication; Molecular biology; DNA; Enzyme; Mutation; Chemistry; Virus; Biochemistry; Human immunodeficiency virus (HIV); Viral load; Gene; Antiretroviral therapy","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002097995,0.0005069402,0.0004505986,0.0002178541,0.0001744583,0.0003705558,0.0002175509,0.0003902107,0.001682082],"category_scores_gemma":[0.0002711337,0.0002211965,0.0003726617,0.0001469805,0.0002534582,0.000121606,0.0002049129,0.0005326257,0.0006442064],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000218459,"about_ca_system_score_gemma":0.000191779,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005619033,"about_ca_topic_score_gemma":0.0005784031,"domain_scores_codex":[0.9997193,0.0000811892,0.00004167275,0.0000462806,0.00006378116,0.00004772571],"domain_scores_gemma":[0.9998479,0.00002453239,0.00005384656,0.00002502207,0.00001013304,0.00003855878],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002449417,0.00007700123,0.0009680576,0.00001678422,0.00001785147,0.0002735541,0.000007380604,0.0001429498,0.9966707,0.00004408927,0.00003716267,0.001499582],"study_design_scores_gemma":[0.0001772126,0.002650433,0.03016924,0.00002137256,0.00008622972,0.006020928,0.00004993993,0.003852088,0.9536483,0.00007342619,0.003222554,0.00002816369],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9985029,0.0002297107,0.0005107487,0.00005070377,0.00001317843,0.00001427688,0.00008493195,0.00002767582,0.0005660383],"genre_scores_gemma":[0.9980972,0.0001727648,0.0007068202,0.00004433974,0.00001086646,0.000006954042,0.0001881338,0.0000167867,0.0007561215],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001682082,"threshold_uncertainty_score":0.005627096,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01062010484899736,"score_gpt":0.2280798887375524,"score_spread":0.2174597838885551,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}