{"id":"W2160908468","doi":"10.1161/circresaha.114.301816","title":"Trimeric Intracellular Cation Channels and Sarcoplasmic/Endoplasmic Reticulum Calcium Homeostasis","year":2014,"lang":"en","type":"review","venue":"Circulation Research","topic":"Ion channel regulation and function","field":"Biochemistry, Genetics and Molecular Biology","cited_by":60,"is_retracted":false,"has_abstract":true,"ca_institutions":"Libin Cardiovascular Institute of Alberta","funders":"National Institute of Arthritis and Musculoskeletal and Skin Diseases; National Heart, Lung, and Blood Institute; National Institute on Aging; Canadian Institutes of Health Research","keywords":"Endoplasmic reticulum; Ryanodine receptor; Cell biology; Calcium signaling; Biology; Intracellular; Depolarization; Calcium; Calcium in biology; Chemistry; Biophysics; Internal medicine; Medicine","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001358381,0.0001850203,0.0002221059,0.0003274463,0.0002313657,0.0004430172,0.0003405712,0.0005653331,0.0008973111],"category_scores_gemma":[0.0001843893,0.00007119292,0.000187128,0.0002741579,0.0003383724,0.0004083293,0.0004807658,0.0003985226,0.000297781],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003628312,"about_ca_system_score_gemma":0.0001951768,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000529616,"about_ca_topic_score_gemma":0.0004898205,"domain_scores_codex":[0.9998813,0.00001311315,0.00001167684,0.00003145329,0.00002991744,0.0000325147],"domain_scores_gemma":[0.9998042,0.00001488791,0.00009354691,0.0000133125,0.00002907327,0.00004502243],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0008793313,0.00007158781,0.006327727,0.0007556909,0.00008927781,0.002112893,0.0002435406,0.001420704,0.87735,0.03217738,0.003556001,0.07501567],"study_design_scores_gemma":[0.0002648437,0.001488734,0.201503,0.0004254812,0.0003151566,0.02157649,0.000882739,0.01567959,0.4968574,0.07958957,0.1812085,0.0002084109],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"review","genre_scores_codex":[0.7448622,0.1833885,0.03716081,0.003670924,0.0005625797,0.00007922976,0.001226636,0.0007259055,0.02832321],"genre_scores_gemma":[0.9573913,0.02905656,0.005900271,0.0009025679,0.0002492266,0.00005599889,0.0007040185,0.00002262159,0.005717476],"genre_candidate":"review","genre_consensus":null,"teacher_disagreement_score":0.0008973111,"threshold_uncertainty_score":0.003001809,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1066038660608685,"score_gpt":0.3903987631668547,"score_spread":0.2837948971059862,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}