{"id":"W2160911021","doi":"10.1093/hmg/ddq311","title":"Genetic ablation of Dicer in adult forebrain neurons results in abnormal tau hyperphosphorylation and neurodegeneration","year":2010,"lang":"en","type":"article","venue":"Human Molecular Genetics","topic":"MicroRNA in disease regulation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":326,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université Laval; Centre hospitalier de l'Université Laval","funders":"H. Lundbeck A/S; Lundbeckfonden; National Research Foundation; Natural Sciences and Engineering Research Council of Canada; Vlaamse regering; European Commission; Brigham and Women's Hospital; Scottish Rite Charitable Foundation of Canada; Danmarks Grundforskningsfond; Agence Nationale de la Recherche","keywords":"Dicer; Biology; Forebrain; Neurodegeneration; microRNA; Hyperphosphorylation; Cell biology; Neuroscience; Cyclin-dependent kinase 5; Kinase; Genetics; RNA interference; Gene; Protein kinase A; RNA; Pathology; Central nervous system; Disease","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001712159,0.0001706916,0.0001371876,0.0001606475,0.00004157469,0.00002253577,0.0001176766,0.0002012569,0.000006034256],"category_scores_gemma":[0.0001209484,0.0002051398,0.000044867,0.0001546817,0.00009338883,0.000008061913,0.00007683868,0.0001442043,0.00000112515],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001338304,"about_ca_system_score_gemma":0.00005129784,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00007049941,"about_ca_topic_score_gemma":0.001724676,"domain_scores_codex":[0.9986197,0.0001002117,0.0004906911,0.0004142489,0.0001681227,0.0002070199],"domain_scores_gemma":[0.999249,0.000009219141,0.0001627878,0.0004017447,0.0001113191,0.00006587619],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.00005811491,0.0000610746,0.02895847,0.00001865895,0.00000546303,0.000005974763,0.00007770627,0.006642214,0.9624765,0.0002561315,0.00002687875,0.00141283],"study_design_scores_gemma":[0.0009920446,0.0001181755,0.6459225,0.00001045736,0.00001181078,0.00000770561,0.000007730217,0.005357287,0.3470957,0.0002126813,0.0001071533,0.0001567491],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9980215,0.0002659388,0.001018672,0.0000501296,0.00006968655,0.0003709729,0.00001930882,0.000006834155,0.0001769497],"genre_scores_gemma":[0.9971702,0.00004541634,0.002314533,0.00008106269,0.00006904657,0.00002046376,0.0002479171,0.00003435408,0.00001706887],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.616964,"threshold_uncertainty_score":0.8365358,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.005825086083527843,"score_gpt":0.2283736952088118,"score_spread":0.222548609125284,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}