{"id":"W2160928326","doi":"10.1016/j.chembiol.2006.12.006","title":"High-Throughput Screening for Human Lysosomal β-N-Acetyl Hexosaminidase Inhibitors Acting as Pharmacological Chaperones","year":2007,"lang":"en","type":"article","venue":"Chemistry & Biology","topic":"Lysosomal Storage Disorders Research","field":"Medicine","cited_by":105,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of British Columbia; University of Toronto; McMaster University; Hospital for Sick Children","funders":"National Institute of Neurological Disorders and Stroke; Canadian Institutes of Health Research","keywords":"Hexosaminidase; Lysosome; Enzyme; Biochemistry; Endoplasmic reticulum; Mutant; High-throughput screening; Gangliosidosis; Biology; Chemistry; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow","insufficient_payload"],"consensus_categories":[],"category_scores_codex":[0.0005550805,0.0003148545,0.0005198551,0.0000620798,0.0003505817,0.00002067611,0.0002512152,0.000504114,0.001067055],"category_scores_gemma":[0.0006578123,0.0002751742,0.0002047788,0.0002230258,0.0004435671,0.0000663543,0.000213502,0.0005310933,0.00003437951],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001536486,"about_ca_system_score_gemma":0.00008955747,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00009927159,"about_ca_topic_score_gemma":0.000005277853,"domain_scores_codex":[0.9975692,0.00003452052,0.0004862318,0.0007053016,0.0002126741,0.0009920866],"domain_scores_gemma":[0.9987155,0.0003234581,0.0001551421,0.000267629,0.0001828803,0.000355343],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0007186826,0.0002434626,0.006454744,0.0001477665,0.0001319087,0.0001284849,0.00009342581,0.00000122075,0.9771254,0.0001309683,0.0004550385,0.01436891],"study_design_scores_gemma":[0.004162744,0.0008377543,0.0009875782,0.00004978451,0.00008803981,0.000175496,0.0007360763,0.00003258284,0.9792665,0.0002354341,0.01309868,0.0003293252],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9936253,0.0004596996,0.001688032,0.001099688,0.0001827851,0.0005580053,0.00001912854,0.0001804514,0.002186867],"genre_scores_gemma":[0.9931324,0.0000234127,0.002987866,0.0004870026,0.001697309,0.0000810012,0.0003777972,0.00004600847,0.001167262],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01403959,"threshold_uncertainty_score":0.99997,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05330242200920352,"score_gpt":0.3878311705619896,"score_spread":0.3345287485527861,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}