{"id":"W2160935759","doi":"10.1128/jvi.02713-07","title":"pRB-E2F1 Complexes Are Resistant to Adenovirus E1A-Mediated Disruption","year":2008,"lang":"en","type":"article","venue":"Journal of Virology","topic":"Virus-based gene therapy research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":25,"is_retracted":false,"has_abstract":true,"ca_institutions":"Western University; Children’s Health Research Institute","funders":"National Cancer Institute; Canadian Institutes of Health Research; Government of Ontario","keywords":"E2F; E2F1; Biology; Retinoblastoma protein; Cell cycle; Transcription factor; Cell biology; Transcription (linguistics); Cancer research; Apoptosis; Genetics; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004055637,0.0001484693,0.0002893103,0.000181087,0.0001129894,0.00001017349,0.000337799,0.0001766748,0.00009949936],"category_scores_gemma":[0.0002388637,0.000127824,0.0001324036,0.0001508912,0.0001568314,0.000005855021,0.0000903919,0.0002477672,0.00006329314],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00004026083,"about_ca_system_score_gemma":0.0001554708,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000007448663,"about_ca_topic_score_gemma":0.0001213599,"domain_scores_codex":[0.9985064,0.0002364986,0.0004232875,0.0002120238,0.0002848989,0.0003368933],"domain_scores_gemma":[0.9989382,0.00003728064,0.0002825206,0.0002788289,0.00024807,0.0002150919],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.008384122,0.0001271077,0.003350713,0.00000627091,0.00009223261,0.000170229,0.00007035067,0.0001833198,0.9798859,0.000005528719,0.00726826,0.0004559222],"study_design_scores_gemma":[0.003755031,0.02920219,0.1392632,0.00003487581,0.00004597136,0.001262752,0.0001548742,0.00004215975,0.7118057,0.0001548012,0.1138031,0.0004753144],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9960618,0.001331991,0.0003406092,0.001836064,0.0001604616,0.0001268832,0.00002543455,0.000006056653,0.0001107184],"genre_scores_gemma":[0.9967868,0.0007169738,0.0003140106,0.001346753,0.000518692,0.00000569436,0.00001880507,0.00002662356,0.0002656108],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.2680803,"threshold_uncertainty_score":0.521251,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0305070358678345,"score_gpt":0.314922215796428,"score_spread":0.2844151799285936,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}