{"id":"W2160939409","doi":"10.4049/jimmunol.164.12.6538","title":"Release of Calcium from Inositol 1,4,5-Trisphosphate Receptor-Regulated Stores by HIV-1 Tat Regulates TNF-α Production in Human Macrophages","year":2000,"lang":"en","type":"article","venue":"The Journal of Immunology","topic":"HIV Research and Treatment","field":"Immunology and Microbiology","cited_by":74,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Manitoba","funders":"","keywords":"Phospholipase C; Calcium in biology; Inositol; Inositol trisphosphate; Calcium; Cell biology; Protein kinase C; Inositol trisphosphate receptor; Intracellular; Biology; Tumor necrosis factor alpha; Phospholipase A2; Inositol phosphate; Receptor; Second messenger system; BAPTA; Chemistry; Signal transduction; Endocrinology; Biochemistry; Internal medicine; Medicine; Enzyme","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001469708,0.0002067948,0.0002867874,0.000193515,0.0002459938,0.0003736499,0.0001154425,0.0002329658,0.0008595039],"category_scores_gemma":[0.0001733945,0.0001540901,0.0002014205,0.0001494688,0.0001886875,0.0002009792,0.0001883119,0.0003858847,0.000336591],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003066606,"about_ca_system_score_gemma":0.0001912279,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004984487,"about_ca_topic_score_gemma":0.0008351369,"domain_scores_codex":[0.9998913,0.00001961064,0.0000127671,0.00001752352,0.00002136522,0.00003749842],"domain_scores_gemma":[0.9999282,0.00001641985,0.0000163639,0.00001043395,0.00001246994,0.00001606871],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003703853,0.00003668305,0.0003657605,0.000033606,0.000004775088,0.000154486,0.00003221216,0.00003273394,0.9979917,0.00004248163,0.0000433496,0.0008919082],"study_design_scores_gemma":[0.0001773851,0.0004680242,0.02797609,0.00003175449,0.00004679173,0.000846463,0.0001399581,0.0008537603,0.9671786,0.0001702546,0.002102189,0.000008621903],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9947567,0.003310719,0.0006791181,0.0001276258,0.00002296669,0.00002161813,0.0001993905,0.00002570477,0.0008562246],"genre_scores_gemma":[0.9960781,0.001635547,0.000709335,0.00005864761,0.00001447524,0.00003903462,0.0001765081,0.00000748419,0.001280906],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0008595039,"threshold_uncertainty_score":0.002875328,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.00877877129233305,"score_gpt":0.2490983688939195,"score_spread":0.2403195976015864,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}