{"id":"W2160949822","doi":"10.1371/journal.ppat.1002355","title":"Novel Anti-bacterial Activities of β-defensin 1 in Human Platelets: Suppression of Pathogen Growth and Signaling of Neutrophil Extracellular Trap Formation","year":2011,"lang":"en","type":"article","venue":"PLoS Pathogens","topic":"Antimicrobial Peptides and Activities","field":"Immunology and Microbiology","cited_by":266,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto; Hospital for Sick Children; SickKids Foundation","funders":"Eunice Kennedy Shriver National Institute of Child Health and Human Development; National Institute of Diabetes and Digestive and Kidney Diseases; National Heart, Lung, and Blood Institute; Canadian Institutes of Health Research; Deutsche Gesellschaft für Kardiologie-Herz und Kreislaufforschung.; University of Utah; National Institutes of Health; Pfizer; American Heart Association","keywords":"Neutrophil extracellular traps; Platelet; Staphylococcus aureus; Antimicrobial peptides; Defensin; Microbiology; Platelet activation; Antimicrobial; Biology; Extracellular; Cell biology; Chemistry; Bacteria; Immunology; Inflammation; Genetics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001166752,0.0002275939,0.0001619313,0.00009817519,0.00007202134,0.0002175764,0.0001186683,0.0001778957,0.000465278],"category_scores_gemma":[0.00009777208,0.00007396429,0.0001334297,0.00007022172,0.00008651978,0.00006277661,0.00009917391,0.0003485647,0.0001249499],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001099604,"about_ca_system_score_gemma":0.00009463978,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001918305,"about_ca_topic_score_gemma":0.0002587349,"domain_scores_codex":[0.9999421,0.00001672767,0.000004793051,0.000009566072,0.00001323856,0.00001363177],"domain_scores_gemma":[0.9999714,0.000009171697,0.000007095454,0.000002721822,0.000002864442,0.000006693922],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001872291,0.00002967813,0.0001353881,0.00004982466,0.000005678557,0.0001347595,0.00001527668,0.00004502833,0.9961776,0.00006085249,0.00006538189,0.003093321],"study_design_scores_gemma":[0.0001053449,0.001340279,0.006994492,0.00001092556,0.00003915006,0.0007640382,0.00002384052,0.001052334,0.9856002,0.00004946814,0.004015597,0.000004237394],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9922553,0.004737287,0.001690236,0.0001690217,0.00002461711,0.00004351874,0.0002132286,0.00003243323,0.0008343813],"genre_scores_gemma":[0.9958475,0.001614966,0.001155984,0.0000875183,0.00002393428,0.00004031215,0.0004828555,0.000003914428,0.0007429499],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.000465278,"threshold_uncertainty_score":0.001556516,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02850272360161091,"score_gpt":0.2071619302392723,"score_spread":0.1786592066376614,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}