{"id":"W2160949822","doi":"10.1371/journal.ppat.1002355","title":"Novel Anti-bacterial Activities of β-defensin 1 in Human Platelets: Suppression of Pathogen Growth and Signaling of Neutrophil Extracellular Trap Formation","year":2011,"lang":"en","type":"article","venue":"PLoS Pathogens","topic":"Antimicrobial Peptides and Activities","field":"Immunology and Microbiology","cited_by":266,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto; Hospital for Sick Children; SickKids Foundation","funders":"Eunice Kennedy Shriver National Institute of Child Health and Human Development; National Institute of Diabetes and Digestive and Kidney Diseases; National Heart, Lung, and Blood Institute; Canadian Institutes of Health Research; Deutsche Gesellschaft für Kardiologie-Herz und Kreislaufforschung.; University of Utah; National Institutes of Health; Pfizer; American Heart Association","keywords":"Neutrophil extracellular traps; Platelet; Staphylococcus aureus; Antimicrobial peptides; Defensin; Microbiology; Platelet activation; Antimicrobial; Biology; Extracellular; Cell biology; Chemistry; Bacteria; Immunology; Inflammation; Genetics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001340266,0.000164743,0.000495536,0.0001890008,0.00006042171,0.000003592366,0.0001007547,0.0002070201,0.00008715062],"category_scores_gemma":[0.00001779468,0.0001522885,0.00009018037,0.00007762011,0.0002910245,0.0002306534,0.00006263745,0.0001357024,6.869609e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000007649579,"about_ca_system_score_gemma":0.00001921996,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001083038,"about_ca_topic_score_gemma":0.00000702028,"domain_scores_codex":[0.9989477,0.0001024281,0.0005216657,0.0001774732,0.0000414283,0.0002092933],"domain_scores_gemma":[0.9993191,0.00006488626,0.0004081679,0.0001427273,0.00005178324,0.0000133492],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002438188,0.0005379456,0.002469976,0.0002722009,0.00006020742,0.000004684081,0.004106079,0.000003081967,0.9917119,0.0003944323,0.000005150439,0.0001904794],"study_design_scores_gemma":[0.0009870415,0.0002742387,0.007078504,0.0002495259,0.00005964301,0.00002391864,0.001001717,0.000009019634,0.9900892,0.00008427496,0.00000376411,0.0001391492],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.998704,0.0002745687,0.0002005229,0.000004593866,0.00009112249,0.0001904885,0.0004278044,0.00001296725,0.0000939653],"genre_scores_gemma":[0.9992011,0.00007938201,0.0005609526,0.000003547915,0.00001561613,0.000003497317,0.0001057382,0.00001746351,0.00001275265],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.004608528,"threshold_uncertainty_score":0.6210144,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02850272360161091,"score_gpt":0.2071619302392723,"score_spread":0.1786592066376614,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}