{"id":"W2160953463","doi":"10.1096/fj.09-143743","title":"New potent dual inhibitors of CK2 and Pim kinases: discovery and structural insights","year":2010,"lang":"en","type":"article","venue":"The FASEB Journal","topic":"Cancer Mechanisms and Therapy","field":"Medicine","cited_by":64,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"College of Natural Resources and Sciences, Humboldt State University; Knut och Alice Wallenbergs Stiftelse; Ontario Ministry of Community and Social Services; GlaxoSmithKline Australia; Institut National Du Cancer; Karolinska Institutet; Ligue Genevoise Contre le Cancer; Institut National de la Santé et de la Recherche Médicale; California Earthquake Authority; Genome Canada; Fondation pour la Recherche Médicale; Hamner Institutes for Health Sciences; Canadian Foundation for AIDS Research; Ontario Innovation Trust; Merck","keywords":"Kinome; Kinase; Threonine; Biochemistry; Casein kinase 1; Serine; Casein kinase 2; Chemistry; Biology; Phosphorylation; Protein kinase A; Cyclin-dependent kinase 2","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002026145,0.0005676564,0.0003786494,0.0002702662,0.000152953,0.0003068074,0.0004079329,0.0002494724,0.001742228],"category_scores_gemma":[0.00006890407,0.0001719418,0.0002699255,0.0001539759,0.0001549833,0.0002697311,0.0002917178,0.0005659091,0.0005594248],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002912043,"about_ca_system_score_gemma":0.000204806,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002879792,"about_ca_topic_score_gemma":0.0005895855,"domain_scores_codex":[0.9999434,0.000009911964,0.000003490467,0.000007745861,0.00001864988,0.00001696856],"domain_scores_gemma":[0.9999745,0.000003216074,0.000005050146,0.000001951515,0.00000385364,0.0000115547],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0007320281,0.0005417351,0.0003403692,0.0007065404,0.00006446821,0.0005759717,0.00005272789,0.003119498,0.9520067,0.003119945,0.001729706,0.03701033],"study_design_scores_gemma":[0.001557109,0.005592021,0.003722321,0.00008839488,0.000231173,0.002342456,0.00006570303,0.01281507,0.8730609,0.001867608,0.09856442,0.00009279354],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.898296,0.05086248,0.02406287,0.001647148,0.0003121851,0.0005815899,0.002208101,0.000395203,0.02163444],"genre_scores_gemma":[0.9404168,0.02543364,0.02175145,0.0006666858,0.00009082924,0.0002303273,0.001511006,0.00003948877,0.00985991],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001742228,"threshold_uncertainty_score":0.005828261,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.007880076050888899,"score_gpt":0.2389026084494946,"score_spread":0.2310225323986057,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}