{"id":"W2160953907","doi":"10.7554/elife.02626","title":"Multi-species, multi-transcription factor binding highlights conserved control of tissue-specific biological pathways","year":2014,"lang":"en","type":"article","venue":"eLife","topic":"RNA Research and Splicing","field":"Biochemistry, Genetics and Molecular Biology","cited_by":107,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto; SickKids Foundation","funders":"European Research Council; Natural Sciences and Engineering Research Council of Canada; EMBO; Canada Research Chairs; Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung; Institut National de la Santé et de la Recherche Médicale; Wellcome; European Molecular Biology Laboratory; Wellcome Trust; Consejo Nacional de Ciencia y Tecnología; Cancer Research UK; Sick Kids Foundation","keywords":"Biology; Transcription factor; Gene; DNA binding site; Conserved sequence; Genetics; Promoter; Genome; Cis-regulatory module; Human genome; Computational biology; DNA sequencing; Gene expression; Enhancer; Peptide sequence","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004125705,0.0001503766,0.0003532206,0.0004012117,0.0003188025,0.0004219068,0.0003386832,0.0003288005,0.001939342],"category_scores_gemma":[0.0004748839,0.0001863666,0.0002593896,0.0001968394,0.0004127869,0.0004373096,0.0003654428,0.0004144241,0.0004269209],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000316975,"about_ca_system_score_gemma":0.0001662577,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007853972,"about_ca_topic_score_gemma":0.002183671,"domain_scores_codex":[0.999575,0.00004297646,0.0000174663,0.0002386018,0.00007189862,0.00005412683],"domain_scores_gemma":[0.9995778,0.000118952,0.0001041017,0.00009026349,0.00004330993,0.0000655534],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00005708462,0.000005907295,0.002219235,0.00003138479,0.00001039412,0.00005561175,0.00003954011,0.0001384551,0.9944852,0.0004532179,0.00004582252,0.002458015],"study_design_scores_gemma":[0.00003214328,0.0003088577,0.35379,0.00003816046,0.00008036598,0.002567969,0.000358907,0.0104496,0.6140375,0.00436316,0.01392036,0.00005291158],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9748258,0.002294887,0.01972514,0.0001553411,0.00002770289,0.00000935617,0.0003238143,0.00019275,0.002445229],"genre_scores_gemma":[0.9911922,0.0002771904,0.006807372,0.00015671,0.00001727151,0.000008392884,0.00031279,0.00005150948,0.00117664],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001939342,"threshold_uncertainty_score":0.006487787,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.06486844271219598,"score_gpt":0.2769052932645588,"score_spread":0.2120368505523628,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}