{"id":"W2160970655","doi":"10.1085/jgp.201311037","title":"Sodium channel selectivity and conduction: Prokaryotes have devised their own molecular strategy","year":2014,"lang":"en","type":"article","venue":"The Journal of General Physiology","topic":"Ion channel regulation and function","field":"Biochemistry, Genetics and Molecular Biology","cited_by":65,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Calgary","funders":"Canadian Institutes of Health Research","keywords":"Selectivity; Chemistry; Sodium channel; Sodium; Potassium channel; Potassium; Conductance; Molecular dynamics; Biophysics; Computational chemistry; Biochemistry; Biology; Organic chemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003783711,0.0001254498,0.0001722628,0.00003765076,0.0001102048,0.00001168808,0.0001090261,0.0001086344,0.00001100533],"category_scores_gemma":[0.00004581849,0.00007693587,0.00007219631,0.00004607869,0.0001278454,0.000008413276,0.00004309955,0.0001334534,0.000001375759],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000007642629,"about_ca_system_score_gemma":0.00004204316,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000007467836,"about_ca_topic_score_gemma":0.00000403476,"domain_scores_codex":[0.9991384,0.0003132032,0.0001954226,0.0001284524,0.0000738534,0.000150713],"domain_scores_gemma":[0.9993797,0.00002014145,0.0002094502,0.0001415642,0.0001933049,0.00005585979],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002810757,0.0000279643,0.00002778068,0.00000633288,0.00005841633,2.617479e-7,0.00005244343,0.003227717,0.9934393,0.0001336959,0.001010448,0.001734533],"study_design_scores_gemma":[0.001090567,0.001626486,0.007208216,0.000009097028,0.00004208196,0.0002810154,0.0001526475,0.005842192,0.9726942,0.005807785,0.005055779,0.0001899099],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9923747,0.0004252325,0.005998017,0.0005764693,0.0003596455,0.00008564338,0.000001671938,0.000004254328,0.0001743287],"genre_scores_gemma":[0.997672,0.0001540387,0.00006235702,0.0004367186,0.001391315,0.000002307572,0.00001265713,0.00001177702,0.0002568583],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.02074511,"threshold_uncertainty_score":0.3137354,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01378666369512697,"score_gpt":0.2357699422655039,"score_spread":0.221983278570377,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}