{"id":"W2160972508","doi":"10.1093/bioinformatics/bts411","title":"From phenotype to genotype: an association study of longitudinal phenotypic markers to Alzheimer's disease relevant SNPs","year":2012,"lang":"en","type":"article","venue":"Bioinformatics","topic":"Genetic Associations and Epidemiology","field":"Biochemistry, Genetics and Molecular Biology","cited_by":71,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"U.S. National Library of Medicine; National Institute on Aging; Genentech; National Institutes of Health; Canadian Institutes of Health Research; University of California, Los Angeles; Servier; Eisai; Northern California Institute for Research and Education; University of California, San Diego; Pfizer; Biogen; BioClinica; Amorfix Life Sciences; Dana Foundation; Bayer HealthCare; Meso Scale Diagnostics; National Center for Research Resources; F. Hoffmann-La Roche; Medpace; Bristol-Myers Squibb; Eli Lilly and Company; AstraZeneca; Novartis Pharmaceuticals Corporation; Synarc; Foundation for the National Institutes of Health; National Science Foundation","keywords":"Single-nucleotide polymorphism; SNP; Genetic association; Genotype; Computational biology; Biology; Imaging genetics; Phenotype; Genetics; Genome-wide association study; Longitudinal study; Neuroimaging; Medicine; Pathology; Neuroscience; Gene","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.005461035,0.0006576809,0.0006615733,0.0007157616,0.0005764389,0.0008249572,0.001001541,0.001043291,0.003944287],"category_scores_gemma":[0.01970135,0.0004073053,0.0009264334,0.001434452,0.00057625,0.0008424393,0.001223726,0.001773861,0.0007856712],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004268179,"about_ca_system_score_gemma":0.0009658479,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.007077538,"about_ca_topic_score_gemma":0.008331683,"domain_scores_codex":[0.9986518,0.0007825342,0.00004660595,0.0003729312,0.00009840883,0.0000477798],"domain_scores_gemma":[0.9878117,0.008921428,0.001002764,0.001213866,0.0006312481,0.0004188291],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.004162791,0.0009783119,0.6444163,0.0004393753,0.001509866,0.002127455,0.001033554,0.07333438,0.006687136,0.009662529,0.02894406,0.2267043],"study_design_scores_gemma":[0.0005462161,0.0008720587,0.2015221,0.0001659279,0.001212729,0.002062225,0.0004052801,0.7146318,0.003482627,0.06425257,0.01070028,0.0001461983],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.7352806,0.001897478,0.243887,0.007352798,0.0002144574,0.0001441028,0.007632266,0.001116725,0.002474587],"genre_scores_gemma":[0.9099146,0.0007340092,0.07884178,0.0008274221,0.0002044712,0.0002222297,0.005814152,0.0001970817,0.003244254],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.007077538,"threshold_uncertainty_score":0.02888107,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02276035959394955,"score_gpt":0.2850777229348396,"score_spread":0.26231736334089,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}