{"id":"W2160985440","doi":"10.1152/ajpcell.00467.2008","title":"Hyperosmotic stress induces Rho/Rho kinase/LIM kinase-mediated cofilin phosphorylation in tubular cells: key role in the osmotically triggered F-actin response","year":2008,"lang":"en","type":"article","venue":"American Journal of Physiology-Cell Physiology","topic":"Cellular Mechanics and Interactions","field":"Biochemistry, Genetics and Molecular Biology","cited_by":68,"is_retracted":false,"has_abstract":true,"ca_institutions":"St. Michael's Hospital","funders":"Canadian Institutes of Health Research","keywords":"Cofilin; Phosphorylation; Cell biology; Actin cytoskeleton; Rho-associated protein kinase; Actin; Actin remodeling; MDia1; Biology; Chemistry; Cytoskeleton; Biochemistry; Cell","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001118305,0.000262516,0.0003291439,0.0001637352,0.0001982759,0.0002369886,0.000125454,0.0002828961,0.00091428],"category_scores_gemma":[0.00007540861,0.0001509663,0.0004294884,0.0001259531,0.0002278735,0.0002326054,0.0001776784,0.0004221296,0.0002309403],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002495314,"about_ca_system_score_gemma":0.0001777818,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004902107,"about_ca_topic_score_gemma":0.0006708247,"domain_scores_codex":[0.9998995,0.00001176314,0.000008905132,0.00001882365,0.00002522814,0.00003563334],"domain_scores_gemma":[0.9999156,0.000009343316,0.00002706617,0.000008612492,0.000008874127,0.00003059033],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00007861395,0.000009268027,0.0001207353,0.00001811239,0.000002081737,0.00004377971,0.000009253738,0.00001222114,0.9995002,0.00001863486,0.000007763633,0.0001793946],"study_design_scores_gemma":[0.00001940129,0.000192608,0.01497484,0.000004156327,0.00001218173,0.0003606635,0.00003942435,0.0008566745,0.9827965,0.0000453531,0.0006911622,0.000006958387],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9967348,0.0009446015,0.001500148,0.00009540396,0.00001345456,0.00002569914,0.0001601789,0.00005150556,0.0004741904],"genre_scores_gemma":[0.9970043,0.0005760422,0.001289319,0.00004118781,0.00001287608,0.00004287652,0.0002987715,0.00001064309,0.0007239265],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00091428,"threshold_uncertainty_score":0.003058553,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.00834023761110198,"score_gpt":0.2245026269125027,"score_spread":0.2161623893014007,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}