{"id":"W2160992646","doi":"10.1128/aac.01387-08","title":"Predictive Value of Pharmacokinetics-Adjusted Phenotypic Susceptibility on Response to Ritonavir-Enhanced Protease Inhibitors (PIs) in Human Immunodeficiency Virus-Infected Subjects Failing Prior PI Therapy","year":2009,"lang":"en","type":"article","venue":"Antimicrobial Agents and Chemotherapy","topic":"HIV/AIDS drug development and treatment","field":"Medicine","cited_by":7,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"National Center for Research Resources; National Institute of Allergy and Infectious Diseases; University of California, Davis; U.S. Public Health Service; Bristol-Myers Squibb; University of Miami; York University; Gilead Sciences; Vanderbilt University; University of Southern California; GlaxoSmithKline; University of Texas Southwestern Medical Center; Pfizer; University of California, San Diego; Deutsches Krebsforschungszentrum; Abbott Laboratories","keywords":"Lopinavir; Ritonavir; Indinavir; Pharmacokinetics; Medicine; Protease inhibitor (pharmacology); Pharmacology; Viral load; Internal medicine; In vivo; Immunology; Gastroenterology; Virus; Biology; Antiretroviral therapy","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001125345,0.0003297633,0.0003821008,0.0002655661,0.0001719589,0.0003623128,0.0001944969,0.0005585933,0.000715366],"category_scores_gemma":[0.00496805,0.0001854629,0.0002551129,0.0002403752,0.0003778578,0.0003390161,0.0002280098,0.0006270339,0.0001469172],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001548017,"about_ca_system_score_gemma":0.0001211912,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004518545,"about_ca_topic_score_gemma":0.0004728889,"domain_scores_codex":[0.9994361,0.0003026673,0.00004819512,0.00009831513,0.00006698648,0.00004771478],"domain_scores_gemma":[0.9955527,0.002384886,0.001139996,0.0003069771,0.0001660246,0.0004493632],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.00318697,0.0001490909,0.9900467,0.000009761404,0.00009650529,0.00007857873,0.00004119809,0.0003270201,0.001557863,0.00003073076,0.00006168432,0.004413933],"study_design_scores_gemma":[0.0001222735,0.002437292,0.9934209,0.000003475576,0.00007011753,0.0003720032,0.00004348609,0.002779206,0.0005335158,0.00007737609,0.0001316473,0.00000870853],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9995307,0.0001353783,0.00006590535,0.0000171163,0.000003276728,0.000006181826,0.0000458611,0.000004446034,0.0001911328],"genre_scores_gemma":[0.9998394,0.00001727334,0.00004445781,0.00001271153,0.000005517644,0.000002222829,0.00004566244,9.100644e-7,0.00003185862],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001125345,"threshold_uncertainty_score":0.005951464,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01379798876933169,"score_gpt":0.2855153913158064,"score_spread":0.2717174025464748,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}