{"id":"W2161000933","doi":"10.1038/tp.2012.26","title":"Discovery of blood transcriptomic markers for depression in animal models and pilot validation in subjects with early-onset major depression","year":2012,"lang":"en","type":"article","venue":"Translational Psychiatry","topic":"Tryptophan and brain disorders","field":"Neuroscience","cited_by":103,"is_retracted":false,"has_abstract":true,"ca_institutions":"Dalhousie University","funders":"National Institutes of Health; Davee Foundation; National Institute of Mental Health; Nationwide Children's Hospital","keywords":"Depression (economics); Animal model; Schizophrenia (object-oriented programming); Transcriptome; Behavioral medicine; Psychiatry; Medicine; Animal models of depression; Psychology; Clinical psychology; Internal medicine; Biology; Genetics; Antidepressant; Anxiety; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0006741282,0.000295082,0.0003095404,0.0003828948,0.0002379293,0.0003059804,0.0001338026,0.0002713429,0.0004221661],"category_scores_gemma":[0.0007212486,0.0001980531,0.0002186105,0.0002490283,0.0002696151,0.0001021304,0.0002638648,0.0003630475,0.00009838607],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001606228,"about_ca_system_score_gemma":0.0001841217,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001176221,"about_ca_topic_score_gemma":0.002969817,"domain_scores_codex":[0.9997368,0.0001103525,0.00001402152,0.00007169271,0.00003244135,0.00003462531],"domain_scores_gemma":[0.9997151,0.00009042108,0.00006602622,0.00005082967,0.00004341112,0.0000342291],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.003056471,0.0006659717,0.4789469,0.00005764549,0.0002116393,0.0003246682,0.0004509604,0.0003469058,0.5022975,0.0001163967,0.0002407584,0.01328418],"study_design_scores_gemma":[0.00007183917,0.001799455,0.9797141,0.000008812919,0.0001389887,0.0004093519,0.0001449404,0.000944582,0.01617696,0.0001122382,0.0004684578,0.00001030775],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9975189,0.0001343425,0.001845441,0.00002262429,0.000004534456,0.00005088684,0.0002580177,0.000007571679,0.0001577307],"genre_scores_gemma":[0.9966678,0.0001196111,0.002282061,0.00005492879,0.000005560741,0.0001057633,0.0005209261,0.000004494096,0.0002387869],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001176221,"threshold_uncertainty_score":0.003565192,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02715166385665363,"score_gpt":0.2632784488099276,"score_spread":0.236126784953274,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}