{"id":"W2161003771","doi":"10.1073/pnas.1402814111","title":"Novel coding, translation, and gene expression of a replicating covalently closed circular RNA of 220 nt","year":2014,"lang":"en","type":"article","venue":"Proceedings of the National Academy of Sciences","topic":"RNA Research and Splicing","field":"Biochemistry, Genetics and Molecular Biology","cited_by":181,"is_retracted":false,"has_abstract":true,"ca_institutions":"Carleton University; University of Toronto","funders":"","keywords":"Ribosome; Translation (biology); Internal ribosome entry site; RNA; Eukaryotic translation; Ribosome profiling; Circular RNA; Biology; Coding region; Genetics; Computational biology; Gene; Protein biosynthesis; 5.8S ribosomal RNA; Messenger RNA","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001148149,0.0002309824,0.0001318809,0.0001540493,0.0002078603,0.0002944014,0.0001783703,0.0002304748,0.0005043235],"category_scores_gemma":[0.0001332599,0.0001394259,0.0002524964,0.00009329972,0.0002557903,0.0001495622,0.0001856434,0.0004633757,0.0002158856],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000376753,"about_ca_system_score_gemma":0.0003639135,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000481731,"about_ca_topic_score_gemma":0.0007314759,"domain_scores_codex":[0.9998893,0.000009548777,0.000008330894,0.0000396453,0.00003413797,0.00001907716],"domain_scores_gemma":[0.9998889,0.00002427835,0.00002036501,0.00002093208,0.00001839792,0.00002709753],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00001480772,0.000008212934,0.00005745235,0.00001072146,8.507677e-7,0.0000577481,0.00001217653,0.00005472859,0.9986319,0.0003814273,0.00002086392,0.0007492017],"study_design_scores_gemma":[0.00001187854,0.0001819415,0.002081829,0.000004561131,0.00001207092,0.0004180053,0.00002415788,0.002581758,0.9891225,0.0001885239,0.005364667,0.000008136572],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9768938,0.0006995547,0.01888702,0.0001629199,0.00009671012,0.0000595957,0.0004072506,0.0001587334,0.002634447],"genre_scores_gemma":[0.964393,0.000406534,0.02575425,0.00006884399,0.00004057588,0.00006200396,0.00205557,0.00009900819,0.007120253],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0005043235,"threshold_uncertainty_score":0.002733469,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04394682983053415,"score_gpt":0.3126304473275325,"score_spread":0.2686836174969983,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}