{"id":"W2161072028","doi":"10.1371/journal.pone.0065448","title":"Kif3a Controls Murine Nephron Number Via GLI3 Repressor, Cell Survival, and Gene Expression in a Lineage-Specific Manner","year":2013,"lang":"en","type":"article","venue":"PLoS ONE","topic":"Renal and related cancers","field":"Biochemistry, Genetics and Molecular Biology","cited_by":15,"is_retracted":false,"has_abstract":true,"ca_institutions":"SickKids Foundation; Hospital for Sick Children; University of Toronto","funders":"Canadian Cancer Society Research Institute; Canadian Institutes of Health Research; Canada Research Chairs; Kidney Foundation of Canada","keywords":"Cilium; Biology; Nephron; Mesenchyme; Cell biology; Ureteric bud; Kidney development; Ciliogenesis; Intraflagellar transport; Repressor; Embryonic stem cell; GLI3; Cancer research; Kidney; Gene expression; Genetics; Embryo; Gene; Mutant","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001196779,0.0002119209,0.0001455679,0.0005010205,0.0002179553,0.0002953911,0.0003131829,0.0002503297,0.001243714],"category_scores_gemma":[0.0001023639,0.0002111394,0.0002185553,0.0002071455,0.0003483126,0.0001369511,0.0002066257,0.0004780099,0.0003586236],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0006524921,"about_ca_system_score_gemma":0.0004013241,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002728687,"about_ca_topic_score_gemma":0.006259201,"domain_scores_codex":[0.9998209,0.00001798422,0.00001762449,0.00004058024,0.00005380712,0.00004917309],"domain_scores_gemma":[0.9998285,0.00001539085,0.0000674644,0.00002053349,0.00001653148,0.00005159595],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00007941807,0.0000143747,0.0002627021,0.00001130912,0.000002801799,0.00002531334,0.00001306891,0.00005828781,0.9986304,0.0001389785,0.00002953897,0.0007337035],"study_design_scores_gemma":[0.000023943,0.00008724266,0.006632801,0.000004746173,0.00001719143,0.0001970716,0.00002356047,0.001116541,0.9893182,0.00009074147,0.002481959,0.00000603736],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9935521,0.0007329064,0.002979702,0.00009088367,0.00001675263,0.00001911203,0.0007442318,0.0002332976,0.001631124],"genre_scores_gemma":[0.9943943,0.0003712869,0.001769006,0.00003939048,0.000003529668,0.00003051275,0.0003953959,0.00005876798,0.002937627],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002728687,"threshold_uncertainty_score":0.005425632,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0129627240615289,"score_gpt":0.2009657442253635,"score_spread":0.1880030201638346,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}