{"id":"W2161090963","doi":"10.1158/1078-0432.ccr-05-2070","title":"Variant diphtheria toxin-interleukin-3 fusion proteins with increased receptor affinity have enhanced cytotoxicity against acute myeloid leukemia progenitors.","year":2006,"lang":"en","type":"article","venue":"Clinical Cancer Research","topic":"Toxin Mechanisms and Immunotoxins","field":"Immunology and Microbiology","cited_by":46,"is_retracted":false,"has_abstract":true,"ca_institutions":"BC Cancer Agency","funders":"National Cancer Institute","keywords":"Myeloid leukemia; Diphtheria toxin; Progenitor cell; Biology; Molecular biology; Cytotoxicity; Leukemia; Fusion protein; Interleukin 3; Cancer research; Receptor; Immunology; Stem cell; Toxin; Interleukin 21; CD8; Cell biology; Immune system; Genetics; Gene; In vitro; Recombinant DNA","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow","research_integrity","insufficient_payload"],"consensus_categories":["insufficient_payload"],"category_scores_codex":[0.003351629,0.000512837,0.0009260143,0.0002255032,0.0009021587,0.0001338724,0.001046032,0.0009611117,0.002755829],"category_scores_gemma":[0.000467195,0.0003892032,0.0003225883,0.0005516616,0.001247307,0.000226619,0.0005746825,0.002709726,0.0008582451],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0008386063,"about_ca_system_score_gemma":0.001729079,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.004378717,"about_ca_topic_score_gemma":0.00192439,"domain_scores_codex":[0.9934611,0.002111331,0.001212907,0.001303195,0.0004040948,0.001507312],"domain_scores_gemma":[0.9969819,0.0006784502,0.0003673846,0.0011065,0.0006858213,0.0001799714],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.005252437,0.0008408182,0.0008880191,0.00003974354,0.000377739,0.00006205519,0.0001373028,0.000007059835,0.9800257,0.0002738168,0.004830625,0.007264702],"study_design_scores_gemma":[0.005700097,0.002667014,0.01075406,0.0002904594,0.00006482656,0.00002191606,0.0002037834,0.00001679987,0.9531226,0.0002711574,0.02627522,0.0006120384],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9921099,0.0005538125,0.0005907515,0.000398852,0.0009296824,0.002552775,0.0003177151,0.0002084314,0.002338063],"genre_scores_gemma":[0.9906774,0.0005818049,0.0009834275,0.000282711,0.0006712029,0.001212894,0.0002787848,0.0001037271,0.005208084],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.02690305,"threshold_uncertainty_score":0.9999197,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04334246977056452,"score_gpt":0.3580409965551613,"score_spread":0.3146985267845968,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}