{"id":"W2161090963","doi":"10.1158/1078-0432.ccr-05-2070","title":"Variant diphtheria toxin-interleukin-3 fusion proteins with increased receptor affinity have enhanced cytotoxicity against acute myeloid leukemia progenitors.","year":2006,"lang":"en","type":"article","venue":"Clinical Cancer Research","topic":"Toxin Mechanisms and Immunotoxins","field":"Immunology and Microbiology","cited_by":46,"is_retracted":false,"has_abstract":true,"ca_institutions":"BC Cancer Agency","funders":"National Cancer Institute","keywords":"Myeloid leukemia; Diphtheria toxin; Progenitor cell; Biology; Molecular biology; Cytotoxicity; Leukemia; Fusion protein; Interleukin 3; Cancer research; Receptor; Immunology; Stem cell; Toxin; Interleukin 21; CD8; Cell biology; Immune system; Genetics; Gene; In vitro; Recombinant DNA","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001324343,0.0002516825,0.0002322644,0.00009105229,0.00006855604,0.0002707676,0.0001399437,0.0002054474,0.000607987],"category_scores_gemma":[0.0001802152,0.00008657391,0.0002021657,0.0001539227,0.000163709,0.0001371507,0.0001444173,0.0004159055,0.0002619477],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003608765,"about_ca_system_score_gemma":0.0001021203,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000407992,"about_ca_topic_score_gemma":0.0005118916,"domain_scores_codex":[0.9998741,0.00002372414,0.00001355936,0.00002138153,0.00004150784,0.0000256571],"domain_scores_gemma":[0.9998919,0.00002903295,0.00003716836,0.00001360528,0.000009278294,0.00001896559],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00009897952,0.00001015415,0.0005970299,0.00001054459,0.000004510031,0.00002611373,0.000007960068,0.0001207657,0.9976926,0.00003598262,0.00001656801,0.001378849],"study_design_scores_gemma":[0.00003212706,0.000772276,0.007667624,0.000003558271,0.00003917311,0.001556197,0.00001924743,0.0012229,0.9862934,0.00003426732,0.002353335,0.000005938218],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9971444,0.0006305058,0.001623899,0.00003595993,0.000006760234,0.00001623036,0.0001363722,0.00003512524,0.0003706662],"genre_scores_gemma":[0.9968455,0.0002346711,0.00214847,0.00002815348,0.000003325496,0.000009546858,0.000381709,0.000009306675,0.0003392691],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.000607987,"threshold_uncertainty_score":0.002618372,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04334246977056452,"score_gpt":0.3580409965551613,"score_spread":0.3146985267845968,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}