{"id":"W2161095558","doi":"10.1093/intimm/12.9.1293","title":"Creating HIV-1 reverse transcriptase cytotoxic T lymphocyte target structures by HLA-A2 heavy chain modifications","year":2000,"lang":"en","type":"article","venue":"International Immunology","topic":"HIV Research and Treatment","field":"Immunology and Microbiology","cited_by":8,"is_retracted":false,"has_abstract":true,"ca_institutions":"Canada Research Chairs","funders":"","keywords":"CTL*; Epitope; Cytotoxic T cell; Subdominant; MHC class I; Human leukocyte antigen; Virology; Biology; CD8; Antigen; Major histocompatibility complex; Immunology; In vitro; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001336766,0.0003510276,0.0001618704,0.0001430528,0.0001280975,0.0004528594,0.0002710711,0.0003352683,0.001162543],"category_scores_gemma":[0.0001805026,0.0002349362,0.0002322748,0.0001268293,0.0001950955,0.0003407086,0.0003282126,0.0006151496,0.0004512136],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001855262,"about_ca_system_score_gemma":0.000126768,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001583162,"about_ca_topic_score_gemma":0.0002254782,"domain_scores_codex":[0.9998885,0.0000234185,0.000008938114,0.00002257347,0.00002697592,0.00002956301],"domain_scores_gemma":[0.9999136,0.00001718273,0.00002810521,0.00001688862,0.000007852913,0.00001637332],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001025865,0.00006655807,0.0001115731,0.00002513062,0.000005395145,0.00007179485,0.00001905008,0.0002661038,0.9963595,0.0003392767,0.00004568684,0.002587409],"study_design_scores_gemma":[0.00004740633,0.0003175254,0.0003814434,0.000002806945,0.000013878,0.0001882371,0.000008958365,0.0008596012,0.9939796,0.00008691936,0.004107418,0.000006274233],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9876481,0.0006803192,0.008976062,0.0001004283,0.00005640709,0.00007390245,0.00008445005,0.0001314288,0.002248899],"genre_scores_gemma":[0.9862549,0.0007253122,0.009223174,0.0001107295,0.00002377076,0.00006945564,0.0001757855,0.00005117969,0.003365659],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001162543,"threshold_uncertainty_score":0.003889024,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01231116137607308,"score_gpt":0.2607208546681652,"score_spread":0.2484096932920922,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}