{"id":"W2161128756","doi":"10.1128/jvi.00963-07","title":"DNA Palindromes with a Modest Arm Length of ≳20 Base Pairs Are a Significant Target for Recombinant Adeno-Associated Virus Vector Integration in the Liver, Muscles, and Heart in Mice","year":2007,"lang":"en","type":"article","venue":"Journal of Virology","topic":"Virus-based gene therapy research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":52,"is_retracted":false,"has_abstract":true,"ca_institutions":"Hospital for Sick Children","funders":"National Institute of Diabetes and Digestive and Kidney Diseases; National Cancer Institute; National Heart, Lung, and Blood Institute; U.S. Department of Health and Human Services","keywords":"Biology; Adeno-associated virus; Recombinant DNA; Vector (molecular biology); Virology; Genetics; DNA; Transduction (biophysics); Molecular biology; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.002022207,0.0001218998,0.0002903611,0.0001740623,0.00003197686,0.000008554854,0.0001715096,0.0001633155,0.000005335619],"category_scores_gemma":[0.0002101384,0.00008212877,0.00006797542,0.0001413122,0.0001096559,0.000007612849,0.0000208243,0.0002606518,1.916392e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00003954691,"about_ca_system_score_gemma":0.0001158866,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00006888194,"about_ca_topic_score_gemma":0.005075854,"domain_scores_codex":[0.9986765,0.0003356134,0.0004104866,0.0001682638,0.0001502497,0.0002589205],"domain_scores_gemma":[0.9991884,0.0001804753,0.0003148022,0.0001240982,0.0001378796,0.00005438051],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.007086548,0.0006926184,0.004529181,0.00001726536,0.00005792921,0.00006449454,0.000335178,0.0001591439,0.9857058,0.000007931778,0.0001584138,0.001185521],"study_design_scores_gemma":[0.007169295,0.04022891,0.1120453,0.0001373532,0.00004916419,0.0001890577,0.001614536,0.001196848,0.8361691,0.0003362667,0.0005991051,0.0002650696],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9972313,0.001327876,0.0003735816,0.0007072299,0.00004605039,0.0002848018,0.00002312454,0.000001260758,0.000004764462],"genre_scores_gemma":[0.9987329,0.0004778364,0.000463535,0.0002300297,0.00004617246,0.00001164117,0.00001592284,0.00001500716,0.000006915014],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1495367,"threshold_uncertainty_score":0.3349114,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02020392835874636,"score_gpt":0.2752827951278626,"score_spread":0.2550788667691163,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}