{"id":"W2161128756","doi":"10.1128/jvi.00963-07","title":"DNA Palindromes with a Modest Arm Length of ≳20 Base Pairs Are a Significant Target for Recombinant Adeno-Associated Virus Vector Integration in the Liver, Muscles, and Heart in Mice","year":2007,"lang":"en","type":"article","venue":"Journal of Virology","topic":"Virus-based gene therapy research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":52,"is_retracted":false,"has_abstract":true,"ca_institutions":"Hospital for Sick Children","funders":"National Institute of Diabetes and Digestive and Kidney Diseases; National Cancer Institute; National Heart, Lung, and Blood Institute; U.S. Department of Health and Human Services","keywords":"Biology; Adeno-associated virus; Recombinant DNA; Vector (molecular biology); Virology; Genetics; DNA; Transduction (biophysics); Molecular biology; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001908976,0.0003635194,0.0002960954,0.0005409002,0.0001350465,0.0002468471,0.0002095122,0.0002459872,0.0009545325],"category_scores_gemma":[0.0001446578,0.000239222,0.000342951,0.0001906406,0.0001389677,0.0001361726,0.0001590984,0.0004610379,0.0005132351],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001143841,"about_ca_system_score_gemma":0.0001000613,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001747652,"about_ca_topic_score_gemma":0.0004242787,"domain_scores_codex":[0.9997708,0.00001711721,0.00001973455,0.00008373336,0.00007585513,0.00003279183],"domain_scores_gemma":[0.9997552,0.0000397046,0.0001239617,0.00002100863,0.00002055675,0.00003967137],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00002030952,0.000004280356,0.0003345779,0.00001057361,0.00000344165,0.00002207125,0.000004359828,0.0000108668,0.9988361,0.00001012275,0.000003563088,0.0007397606],"study_design_scores_gemma":[0.000009190262,0.000469988,0.03217228,0.00001094009,0.00004796484,0.001204253,0.00001867686,0.0004959553,0.9640601,0.00005032913,0.001451836,0.000008575651],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9812675,0.002331977,0.01457459,0.00003068081,0.00001157002,0.00005273632,0.000470074,0.0001750052,0.001085935],"genre_scores_gemma":[0.9823569,0.001156808,0.01230733,0.00004267934,0.00001287375,0.00006629877,0.001497125,0.00005295941,0.002507057],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0009545325,"threshold_uncertainty_score":0.003193259,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02020392835874636,"score_gpt":0.2752827951278626,"score_spread":0.2550788667691163,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}