{"id":"W2161185495","doi":"10.1126/science.1235872","title":"Predicting and Manipulating Cardiac Drug Inactivation by the Human Gut Bacterium <i>Eggerthella lenta</i>","year":2013,"lang":"en","type":"article","venue":"Science","topic":"Gut microbiota and health","field":"Biochemistry, Genetics and Molecular Biology","cited_by":688,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"National Institute of Diabetes and Digestive and Kidney Diseases; National Institute of General Medical Sciences; Canadian Institutes of Health Research","keywords":"Digoxin; Cardiac glycoside; Metabolite; Arginine; Pharmacology; Drug; Chemistry; Microbiology; Medicine; Biology; Internal medicine; Biochemistry; Heart failure; Amino acid","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001726392,0.0002991106,0.000213687,0.0001209104,0.0001684217,0.0004388564,0.0001444662,0.0003742808,0.0003835273],"category_scores_gemma":[0.0002704487,0.00009449234,0.0001949908,0.0001184392,0.0001727604,0.0002490584,0.00039145,0.0003632833,0.0002145121],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002602648,"about_ca_system_score_gemma":0.0002734551,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002159045,"about_ca_topic_score_gemma":0.003204648,"domain_scores_codex":[0.9998503,0.00002279508,0.00001112409,0.00005137656,0.00003849783,0.00002589253],"domain_scores_gemma":[0.9999304,0.00001740245,0.00002758326,0.000006162732,0.00001093386,0.000007508751],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00006412695,0.00004180962,0.004198279,0.00004681536,0.000006851856,0.0000492563,0.00002843086,0.0003658727,0.9896326,0.00007317189,0.00004255268,0.005450209],"study_design_scores_gemma":[0.00001477565,0.0006720133,0.0410035,0.00002892762,0.00005393024,0.0002679148,0.0003117856,0.005378935,0.9471438,0.0002381155,0.004868235,0.00001806707],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9927731,0.000716268,0.003960677,0.0003697578,0.00002212889,0.00004458421,0.0004566117,0.00006656548,0.001590213],"genre_scores_gemma":[0.9840832,0.001157552,0.012509,0.0001611917,0.00001127317,0.00002706582,0.0006775421,0.0000254142,0.001347668],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002159045,"threshold_uncertainty_score":0.004292965,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.007301833220619471,"score_gpt":0.2444853334000928,"score_spread":0.2371835001794733,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}