{"id":"W2161203592","doi":"10.1002/9780470571224.pse322","title":"Pharmacokinetics Of Nucleic‐Acid‐Based Therapeutics","year":2010,"lang":"en","type":"other","venue":"Pharmaceutical Sciences Encyclopedia","topic":"RNA Interference and Gene Delivery","field":"Biochemistry, Genetics and Molecular Biology","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"London Health Sciences Centre; Lawson Health Research Institute; Cancer Care Ontario; Western University","funders":"","keywords":"Nucleic acid; Oligonucleotide; Pharmacokinetics; Computational biology; Chemistry; Pharmacology; Biology; Gene; Biochemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow","insufficient_payload"],"consensus_categories":[],"category_scores_codex":[0.0002543487,0.0003394912,0.0002911652,0.0001461942,0.00006097178,0.00002741412,0.0008553524,0.0004370855,0.002690752],"category_scores_gemma":[0.00003670503,0.0002859279,0.0001691434,0.0002279709,0.0008739176,0.000003517409,0.000162643,0.0003517973,0.0000865495],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00000632907,"about_ca_system_score_gemma":0.0002172857,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00002831378,"about_ca_topic_score_gemma":0.00004367399,"domain_scores_codex":[0.9981646,0.00007302251,0.000314471,0.0005897016,0.0004122191,0.0004459836],"domain_scores_gemma":[0.9991607,0.00002454085,0.0002041556,0.0003674924,0.00006777656,0.0001753245],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"not_applicable","study_design_scores_codex":[0.00007286549,0.0002762506,0.001319311,0.0001272481,0.0001365772,0.000007164175,0.00002446457,0.00001791881,0.7653258,0.0001116061,0.1945397,0.038041],"study_design_scores_gemma":[0.0003405043,0.0001937401,0.00003022737,0.00003548455,0.00009195601,0.000003144862,0.000008143564,0.0003975409,0.1951431,0.00002148417,0.8034262,0.0003084851],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"other","genre_gemma":"empirical","genre_scores_codex":[0.01150602,0.006424643,0.0008267762,0.0002829267,0.00186151,0.0004353886,0.0001981753,0.00006983535,0.9783947],"genre_scores_gemma":[0.4821054,0.05159705,0.01572428,0.01006122,0.007231373,0.000140546,0.0004568388,0.001214428,0.4314688],"genre_candidate":"other","genre_consensus":null,"teacher_disagreement_score":0.6088865,"threshold_uncertainty_score":0.9999593,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03380258024006753,"score_gpt":0.3432769030466246,"score_spread":0.3094743228065571,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}