{"id":"W2161230440","doi":"10.1155/2014/191863","title":"The Role of the Blood-Brain Barrier in the Pathogenesis of Senile Plaques in Alzheimer’s Disease","year":2014,"lang":"en","type":"article","venue":"International Journal of Alzheimer s Disease","topic":"Alzheimer's disease research and treatments","field":"Medicine","cited_by":59,"is_retracted":false,"has_abstract":true,"ca_institutions":"Brock University; McMaster University; Hamilton Health Sciences","funders":"","keywords":"Rage (emotion); Enos; Pathogenesis; Alzheimer's disease; Blood–brain barrier; Endocrinology; Internal medicine; Microvessel; Senile plaques; Glycation; Amyloid beta; Medicine; Receptor; Chemistry; Biology; Pathology; Nitric oxide; Angiogenesis; Nitric oxide synthase; Disease; Neuroscience; Central nervous system","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0009251036,0.0002110855,0.0003312429,0.0002435061,0.00007992356,0.0000426165,0.0008794864,0.00004573102,0.00007736277],"category_scores_gemma":[0.0008295266,0.0001058063,0.0004914341,0.0002643194,0.0003355701,0.0001845082,0.0001390148,0.0002834638,0.000005961821],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00003585186,"about_ca_system_score_gemma":0.0007588491,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00009823071,"about_ca_topic_score_gemma":0.00003143179,"domain_scores_codex":[0.996497,0.0005624655,0.0008360518,0.0001963402,0.001612401,0.0002957041],"domain_scores_gemma":[0.9973744,0.0006322374,0.0005146918,0.0005033236,0.000537123,0.0004382854],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.005517328,0.003268902,0.9514464,0.00002263643,0.0136079,0.0007725774,0.0006692227,0.0001720304,0.0008058953,0.003045416,0.0007374948,0.01993423],"study_design_scores_gemma":[0.003016254,0.0001677437,0.9844717,0.0003133855,0.003042226,0.00004045896,0.0003694706,0.0005218344,0.002212189,0.004263479,0.001458045,0.0001232387],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.933024,0.05792402,0.00000360328,0.007618944,0.0002349621,0.0005438685,0.0002108984,0.000005426269,0.0004343061],"genre_scores_gemma":[0.9987776,0.0003892207,0.00003629399,0.0004810613,0.0002322016,0.00003405208,0.0000170635,0.0000234814,0.000008984892],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.06575367,"threshold_uncertainty_score":0.4314656,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01634104443731023,"score_gpt":0.3044166611579931,"score_spread":0.2880756167206829,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}